What is garcinia cambogia?
Garcinia cambogia is a tropical fruit that is native to Indonesia. It is also known as the Malabar tamarind. The fruit has a sour taste and is often used in cooking, particularly in traditional dishes in South India and Southeast Asia. The rind of the fruit is used to extract a substance called hydroxycitric acid (HCA), which is believed to have weight loss and other health benefits.
Garcinia cambogia supplements are believed to work by inhibiting the enzyme called citrate lyase, which plays a role in the utilization of fat in the body. By inhibiting this enzyme, garcinia cambogia supplements may reduce the storage of fat and potentially lead to weight loss.
In addition to its role in fat production, citrate lyase is also involved in the production of cholesterol and other lipids. Some studies have suggested that inhibiting the activity of citrate lyase may also support healthy cholesterol levels.
Hydroxycitric acid (HCA) is also thought to have other effects on the body. Some studies have suggested that HCA may increase levels of serotonin, a neurotransmitter that plays a role in regulating mood and appetite. It is thought that increasing levels of serotonin may help to reduce cravings for unhealthy foods and potentially lead to weight loss.
Neurotransmitters are chemical messengers involved in the transmission of nerve impulses between neurons (nerve cells) in the brain. Serotonin is involved in a wide range of physiological and behavioral processes, including mood, anxiety, appetite, sleep, and aggression.
Serotonin is produced by neurons in the brain and is also found in the digestive system, blood platelets, and other tissues in the body. It is thought to play a role in maintaining a sense of well-being and happiness.
Serotonin is also involved in the regulation of appetite and digestion. It is believed to play a role in the sensation of fullness and satiety after a meal and may help to regulate food intake and body weight.
Serotonin is produced from the amino acid tryptophan and is regulated by a number of factors, including diet, exercise, stress, and medications. Some medications, such as selective serotonin reuptake inhibitors (SSRIs), work by increasing the availability of serotonin in the brain.
There have been several studies conducted on the effectiveness of garcinia cambogia supplements for weight loss. The results of these studies have been mixed, with some finding that garcinia cambogia may be effective in helping with weight loss, while others have not found any significant benefits.
One study published in the Journal of the American Medical Association in 1998 found that garcinia cambogia was no more effective than a placebo in promoting weight loss. However, a meta-analysis of nine randomized controlled trials published in 2011 found that garcinia cambogia supplements were associated with a small, statistically significant reduction in body weight compared to placebo.
Another study published in the Journal of Obesity in 2011 found that garcinia cambogia was associated with a significant reduction in body weight and waist circumference, as well as a decrease in cholesterol levels. However, a review published in the Journal of the Academy of Nutrition and Dietetics in 2013 found that the evidence for the effectiveness of garcinia cambogia for weight loss was inconclusive.
There have been several studies conducted on the effects of inhibiting citrate lyase, the enzyme involved in the production of fat in the body. Some studies have suggested that inhibiting citrate lyase may be associated with weight loss and a reduction in cholesterol levels.
One study published in the journal Lipids in Health and Disease in 2010 found that treatment with a citrate lyase inhibitor reduced body weight and improved lipid levels in obese mice. Another study published in the Journal of Lipid Research in 2005 found that treatment with a citrate lyase inhibitor reduced body weight, cholesterol levels, and liver fat content in obese rats.
The results of these studies may not necessarily be applicable to humans. More research is needed to fully understand the full effects of inhibiting citrate lyase in humans. It is always best to speak with a healthcare provider before taking any dietary supplement or making any changes to your diet or exercise routine.
Most if not all dietary supplements will have conflicting studies regarding efficacy. One reason is the design of most clinical studies also involve caloric restriction in addition to supplementation. And while caloric restriction works for those who can maintain a restricted diet for a long period of time, these studies show little difference between those who restrict the diet (placebo group), and those who restrict the diet and also supplement the diet with the ingredient being studied (control group). Any supplement that promotes the burning of energy is doomed for failure with this study design as dietary restriction forces the body to conserve energy. Storing fat to conserve energy is a survival mechanism built into our DNA. Attempts to alter this genetic trait are both unlikely and unwise.