|
Recent Articles
Commentary
Dear Mr. Morgenthaler,
Thank you for the “Health & Wellness Update.” I look forward to each issue, and the solid information it provides.
- John V.
Sun City, AZ
Praise for
Smart Publications
Health & Wellness Update
"For sometime now I have enjoyed reading Smart Publications. They are beautifully structured, well written and educational"
- John W.
Durham, NC
"Wealth of information for anyone that chooses alternative healing methods. It's an education in itself just to read one of these newsletters! Every time I get one I read it from cover to cover! Easy to understand and easy to decipher when looking for products. Well done! It's a joy to read."
- B. White
Oxnard, CA
|
Adrafinil:
Alertness Without Stimulation
Adrafinil is the prototype of a new class of smart drug — the eugeroics (i.e., "good arousal") — designed to promote vigilance and alertness. Developed by the French pharmaceutical company Lafon Laboratories, adrafinil (brand name, Olmifon) has been approved in many European countries for treating narcolepsy, a condition characterized by excessive daytime sleepiness and other unusual symptoms.1
Non-narcoleptic users generally find that adrafinil gives them increased energy and reduces fatigue, while improving cognitive function, mental focus, concentration, and memory. It has been reported that quiet people who take adrafinil become more talkative, reserved people become more open, and passive people become more active.
Of course, many stimulant drugs, ranging from caffeine to methamphetamine, are known to produce similar alerting/energizing effects. Adrafinil has been described by some users as a "kinder, gentler" stimulant, because it provides these benefits but usually with much less of the anxiety, agitation, insomnia, associated with conventional stimulants.
Adrafinil's effects are more subtle than those of the stimulants you may be used to, building over a period of days to months. They appear to be based on its ability to selectively stimulate 1-adrenergic receptors in the brain.2 These receptors normally respond to norepinephrine (noradrenaline), a neurotransmitter linked to alertness, learning, and memory. This is in contrast to conventional stimulants, which stimulate a broader spectrum of brain receptors, including those involving dopamine. Its more focused activity profile may account for adrafinil's relative lack of adverse side effects.
Dosing
The standard dose is 2 to 4 300-mg tablets per day for improving cognitive function, although some people may find lower doses produce a desirable degree of improvement. Higher doses have been used to treat narcolepsy.
Safety
Although adrafinil is generally regarded as quite safe, a few adverse effects have been reported with long-term use, including stomach pain, skin irritations, and a feeling of "inner tension." Long-term use has also been associated with occasional instances of elevated liver enzymes, specifically SGOT, SGPT, GGPT, and hepatic alkaline phosphatase. Thus, if you plan to use adrafinil for an extended period of time, we suggest you have your liver function tested to establish a baseline, and then after 3 months and again every 6 months thereafter. If abnormalities appear, reducing the dose or stopping the drug should permit a return to normal.3
Availability
Adrafinil (Olmifon) is not approved for sale in the US. However, individuals can order small amounts for personal use. [Check the CERI website (http://www.ceri.com) for a more extensive discussion of the regulations and risks involved in ordering drugs from overseas.] It is available by mail from sources listed on our page at: How to Order Your Pharmaceuticals from Overseas.
References
- Pascoe P. Drugs and the sleep-wakefulness continuum. Pharmacol Ther. 1994;61:227- 236.
- Lin J, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M. Role of catecholamines in modafinil- and amphetamine-induced wakefulness, a comparative pharmacological study in the cat. Brain Res. 1992;591:319-326.
- Fowkes S. Adrafinil and modafinil. Smart Drug News. 1994;3:1-5. [A short but technically excellent review]
Copyright © 2008 - Smart Publications
POB 4667 - Petaluma, CA 94955
1-800-976-2783
888-998-6889 (fax)
|
Subscribe
to Smart Publications
E-newsletter
and receive weekly e-alerts from the world of nutritional medicine.
Just type your email address below and click on submit (unsubscribe anytime.)
Subscribe...to
Smart Publications Health & Wellness Update
the 16-page monthly newsletter.
and receive the latest information from the world of nutritional medicine.
>> subscribe for free!
Advertisement
FREE
Welcome Kit
from Health Freedom Nutrition
Complete product listing and discount offers included!
>> request a kit
|
