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Supplemental Facts

Growing Interest in Eurycoma Longifolia as an aphrodisiac


Scientific research of the potential aphrodisiac properties of eurycoma continues to support this traditional use. Recent studies conducted at University of Science, Malaysia, show that extracts of eurycoma longifolia enhance sexual motivation in middle aged mice. Because of the interest in eurycoma within Malaysia (one of eurycoma's native lands), the Malaysian government has teamed up with researchers in the U.S. at the Massachusetts Institute of Technology (MIT), under the Malaysia-MIT Biotechnology Partnership Program, to study both the bioactive components in eurycoma and ways to sustainably grow and harvest this remarkable plant.1,2
1. Ang HH, Lee KL, Kiyoshi M. Eurycoma longifolia tongkat ali enhances sexual motivation in middle-aged male mice. J Basic Clin Physiol Pharmacol. 2003;14(3):301-8.

2. Ang HH, Ngai TH, Tan TH. Effects of Eurycoma longifolia tongkat ali on sexual qualities in middle aged male rats. Phytomedicine. 2003;10(6-7):590-3.


Yohimbe Bark Extract Assists Libido

Yohimbe is an herb that has been in use for hundreds of years to assist man in maintaining his libido. This herb is called "yohimbe" the inner bark of the tropical West African tree. Corynanthe Yohimbe. Yohimbe bark has long been known to the natives of West Africa as an effective rejuvenator. It increases libido, but its primary action is to increase blood flow to erectile tissue.

Yohimbe bark affects both the male and female reproductive, nervous, circulatory, and respiratory systems. It contains an alkaloid, yohimbine, that produces blood vessel engorgement in the pelvic area and therefore stimulates the lower center of the spinal cord. This stimulation can cause a strong aphrodisiac effect. Yohimbe has been useful in treating certain cases of diminished sexual interest. It's generally of no value when impotency stems from organic nerve troubles, and it can be harmful when used for impotency caused by chronic inflammation of the sexual organs.

Siberian Ginseng (Eleutherococcus)

Traditionally used as an "adaptogen", or a substance that increases adaptation to stress, ongoing research into the effects of Siberian ginseng has expanded its potential uses. In the case of its anti-stress, anti-fatigue, and performance enhancing properties, a recent study confirmed that extracts of eleutherococcus significantly prolongs exercise ability, while lessening the negative effects of stress on the body.1

Research conducted in Russia examined the effects of Siberian ginseng on memory, as well as light and color visual acuity.2 It was shown that Siberian ginseng improves both short-term memory and visual perception; two effects certain to be of benefit for our aging population. Another recent study looked at the effect of Siberian ginseng on the "quality of life" in elderly patients.3 Beneficial effects without any side effects were seen after administration of Siberian ginseng, with 3 times more patients feeling improvements in the active therapy group than the placebo group.

In addition, by supporting healthy uterine function, Siberian ginseng may be useful in preventing female infertility. Males may experience an increased sperm count (rotate it with Panax ginseng for this purpose). Animal studies indicate that the herb can even boost testosterone levels and thus help reverse certain cases of male impotence. 4
  1. Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol. 2004 Dec;95(2-3):447-53.

  2. Arushanian EB, Baida OA, Mastiagin SS, et al. [Effect of eleutherococcus on short-term memory and visual perception in healthy humans] [Article in Russian] Eksp Klin Farmakol. 2003 Sep-Oct;66(5):10-3.

  3. Cicero AF, Derosa G, Brillante R, et al. Effects of Siberian ginseng (Eleutherococcus senticosus maxim) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl. 2004;(9):69-73.

  4. Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S.Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):473-80. Epub 2004 Apr 17.

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A Healthy Love Life Means A Healthier You!

A Powerful, Natural Arsenal Combats Impotence, Slow Sexual Response, Lack of Desire, Inability to Have Orgasms, and Many Other Common Sexual Dysfunctions.

No one wants to face it, much less talk about it, yet it's so common that each of us will likely experience it at one time or another during our lives: Sexual Dysfunction.

Sexual dysfunction refers to a variety of ailments including "lack of sexual desire, difficulty becoming aroused, inability to achieve orgasm, erection problems in men, lubrication problems in women and pain during intercourse." 15 Untreated, sexual dysfunction can have devastating effects on self-esteem, health, marriage, career, and friendships.

The New York Times reports, "an estimated 30 million men suffer at one time or another from some degree of male erectile dysfunction, [yet] only 2.76 million visited doctors last year with the complaint." 16

Sexual dysfunction is even more common among women. A recent University of Chicago study found that 43% of women surveyed reported sexual problems associated with stress. 17

Not only is sexual dysfunction far more widespread than previously thought, in our modern overworked world, it is also growing rapidly, and now even affects some people in their late teens.

The good news is that thanks to recent advances in nutrition and medical science, many if not most cases of sexual dysfunction can either be greatly improved or cured entirely—without dangerous drugs, surgery or other invasive techniques. Further, with modern prosexual vitamins and nutrients, dramatic improvement—up to and including elimination of sexual problems—can occur in as little as a few weeks or even days, without the high costs of surgery or prescription drugs.

Causes of sexual dysfunction

Sexual dysfunction is not a single malady but rather a number of different maladies, so there is no single cause but rather a constellation of causes.
  • Stress
  • Lack of Sleep
  • Poor Nutrition
  • Prescription Drugs
  • Poor Health
  • Hormone Imbalances
  • Depression
  • Illness
  • Menopause
  • Disease
  • Aging

The two biggest mistakes most people make in dealing with sexual dysfunction

The first mistake is assuming that your sexual problems are unique or unusual. As the studies cited above demonstrate, sexual problems are far, far more widespread than even medical professionals previously realized. Yet the vast majority of people suffering from them do nothing to treat them and in many cases won't even talk about them.

The second mistake is believing that greatly reduced sexual drive and ability is a natural result of getting older. In fact, prosexual vitamins and nutrients can maintain a high sex drive and ability at almost any age.

Why do so many people do nothing about sexual problems? Perhaps it's a vestige of our Puritan heritage, which equated pleasurable sex with sin. Or maybe it's our sex-obsessed culture which makes us ashamed to admit we don't have the sexual energy and interest we once did.

Whatever the cause, ignoring or doing nothing about sexual dysfunction greatly diminishes your quality of life and may lead to many other health issues.

Sex and health

Sexual health is inseparable from your overall health. If you improve your general state of health, you will improve your sexual activities. At the same time, enhancing sexual vitality and improving your sex life has a positive impact on your overall health.

Sex has many beneficial physical effects, including improved blood flow and the release of male and female hormones which improve overall health. The pleasure sex affords makes most people happier with their lives and thereby contributes to high self-esteem and a sense of satisfaction and fulfillment in life.

Sex also performs the vital sociological function of creating a strong-bond between partners, leading to lasting relationships, marriage, and a stable home for children.

Conversely, lack of sex, and inability to perform and enjoy sex is a causative factor in many psychological disorders, and a contributory factor in many physical disorders.

Treating sexual dysfunctions with prosexual nutrients

During the last few decades, tremendous progress has been made in treating sexual disorders, particularly with the development of a number of "prosexual" drugs.

A prosexual drug or nutrient is simply any substance that can improve sex or sexual health.

Generally speaking, there are three major ways in which prosexual substances enhance sex:
  1. They increase ability to perform and enjoy sex—including frequency and duration of erection in men ... and arousal, lubrication, and orgasms for women.

  2. They increase desire for sex (libido).

  3. They improve your general state of health.

During the last 50 years, many prosexual nutrients and substances have been identified which are important for sexual function and enjoyment. Here are seven of the most important. Together they greatly enhance ability and desire for sex.

Prosexual Nutrient #1
TESTOSTERONE:
Essential for both male and female sexuality

Testosterone is the single most important single prosexual substance for both men and women. The very word "testosterone" is virtually synonymous with "sexuality."

There are many, well-documented studies of the benefits of testosterone, including heightened sexuality, increased muscle and bone strength, improved cardiovascular health, elevated mood, and increased overall energy.

While the importance of testosterone for male sexuality is generally well known, what most people don't realize is that testosterone is also essential for female sexuality. Without testosterone, women don't have any sex drive at all.

The main difference in the role of testosterone for men and women is that women naturally have much lower levels, which explains why women generally have a lower sex drive than men. After menopause, many women have extremely low testosterone levels, and thus a very low sex drive.

As you age, testosterone levels fall ... and sex drive too

For both sexes, there is substantial evidence from cross-sectional studies (which compare many people of different ages) showing that as we age, testosterone levels decrease.

Many competent doctors are unaware of this for one simple reason: Although total testosterone levels stay about the same in most men until they are 50 or 60, the really important factor is free testosterone—which appears to decline steadily from age 18, as indicated in the below graph.

Graph

Figure 1. Data from a cross-sectional study showing that total and free testosterone both decline with age, while SHBG (sex hormone binding globulin) rises. (Adapted from Vermeulen, 1993)

This result was confirmed by another cross-sectional study—the Massachusetts Male Aging Study. In this study, researchers evaluated hormone levels in a large group of men between 39 and 70. Overall, they found that in healthy men, free testosterone declines at 1.2% per year. At the same time, the levels of SHBG—along with SHBG-bound testosterone—rose at a rate of 1.2%. If you subtract out the SHBG-bound testosterone, which is inactive, the decline in testosterone is much greater. 18

Testosterone in women also declines with age—and replacing it greatly enhances sex

Similar effects are also present in women. As women enter menopause, androstenedione production in their ovaries takes a sharp dive, decreasing by about 50%. Although the adrenal glands continue to produce some androstenedione, they produce far less than the ovaries, and this production too, declines with age. 19 This contributes to a significant decline in testosterone levels. 20

For decades it has been clear that "testosterone replacement" regimens usually improve sexual function and enjoyment. Well-controlled studies of these regimens have shown that postmenopausal women who take "testosterone," in addition to "estrogen" supplements have a higher level of sexual desire, more sexual fantasies, and greater sexual arousal than do women who take "estrogen alone or no hormonal treatments." 21, 22, 23

One word of caution: Proper testosterone dosage is extremely important for women. Take too little and you have no sex drive. Take too much and you can grow facial hair and start to exhibit other male characteristics.

Problems caused by low testosterone

According to internationally renowned nutritional medicine physician, Dr. Johnathan Wright, 24 effects of low testosterone levels include a long-list of health and emotional problems including:
  • Decreased libido and potency
  • Early senility
  • Memory failure
  • Reduced intellectual agility
  • Loss of ability to concentrate
  • Moodiness/emotionality
  • Depression
  • Reduced activity
  • Increased incidence of atherosclerosis
  • Great timidity
  • General tiredness
  • Nervousness/anxiety
  • Touchiness/irritability
  • Feeling weak
  • Reduced interest in surroundings
  • Hypochondria
  • Inner unrest

Availability of testosterone

As a Schedule 3 drug, testosterone can only be obtained and possessed with a prescription from your doctor. Also, many testosterone precursors have been banned due to suspected misuse by professional athletes. Popular herbal alternatives include tribulus terrestris and eurycoma longifolia, both of which have positive effects on testosterone metabolism.

One of the promising herbs for rejuvenating sexual function that has been diminished by a lack of testosterone is eurycoma longifolia.  Traditionally used to enhance sexual function, especially in Malaysia, eurycoma has been the subject of intensive research by scientists at the Massachusetts Institute of Technology (MIT), in conjuction with Malaysian researchers.  One of the notable findings has been the ability of eurycoma to significantly enhance sexual function in laboratory animals that have been castrated to drastically diminish testosterone levels.25  It has been hypothesized that eurycoma increases the amount of biologically active testosterone within the body.  The ability of eurycoma to stimulate sexual functioning, despite low testosterone levels, makes it a powerful natural alternative to testosterone replacement therapy.

Current research

As eurycoma is becoming a popular supplement around the world for sexual enhancement, more and more scientists are interested in determining exactly how and why it works. The Forest Research Institute of Malaysia (FRIM), in cooperation with the Massachusetts Institute of Technology (MIT), has an ongoing five-year Malaysia-MIT Biotechnology Partnership Program (MMBPP) to determine the herb's health benefits and to see if it works as an aphrodisiac because it increases testosterone. In Thailand, the Faculty of Science of the Mahidol University is investigating the active compounds in eurycoma. And an Indonesian pharmaceutical company is also testing the herb.14

There have been quite a few studies on the effect that eurycoma has on the sexual behavior of male rats which support its folk use as an aphrodisiac. The effects of eurycoma were studied on sexually experienced male rats, castrated rats, sexually inexperienced rats, and middle-aged rats. All studies indicated an increase in the rats' sexual activity.2-10

For instance, in a recent study at the School of Pharmaceutical Sciences, University of Science, Malaysia, the effects of eurycoma were studied on the orientation activities of middle-aged rats towards females. The male rats were given eurycoma extract twice daily for ten days. When compared to the controls, the treated male rats showed more interest in the female rats in terms of sniffing, licking, and mounting. The male rats were also more interested in their environment which they expressed by climbing, exploring, and self-grooming. The study concluded that eurycoma has a definite effect on the orientation activities of middle-aged male rats.11

In a more dramatic study of the aphrodisiac property of eurycoma on sexually inexperienced male rats, an electric grid was used in the rats' cages to deter them from crossing over to the cage with the female rats. The rats treated with eurycoma were willing to overcome the intensity of the grid current to reach the receptive female rats. The untreated rats, however, did not pursue the female rats.

Results showed that eurycoma continued to enhance and also maintain a high level of the total number of successful crossovers, mountings, intromissions and ejaculations during the 9-12 week observation period. In conclusion, these results further enhanced and strengthened the aphrodisiac property of eurycoma longifolia. 12

Additionally, other studies have determined that eurycoma's chemical constituents called quassinoids were found to exhibit anti-tumor and anti-parasitic activities.13

Prosexual Nutrient #2:
ARGININE
Greater staying power and intensity of sexual response

Arginine is an essential amino acid, one of the building blocks of proteins in the body. Arginine is available as a supplement known as "L-arginine."

By increasing blood flow to the penis, L-arginine increases the size, hardness, and frequency of erections for men. For women, L-arginine increases "staying power." One highly athletic, 30-something woman talked about the time she told her doctor about her L-arginine use:

"My doctor almost fell off his chair when I told him how many times a night I do it. He's definitely taking arginine now, too."

Both men and women report that L-arginine seems to increase their libido or desire for sex. Reports also suggest that L-arginine supplements can improve fertility in men who have low sperm counts or poor sperm motility (activity).

How L-arginine works: Just say "NO"

L-arginine is the main source of the primary molecule responsible for sexual arousal and erections: nitrogen.

In the 1990s, scientists discovered that a simple gas—known as nitric oxide or "NO"—is essential for erections. Without arginine in the diet, there would be no NO, and without NO there would be no erections.

Nutritional expert, Dr. Jonathan Wright, explains the mechanism: "Molecules of NO are generated when an enzyme called NO synthase (NOS), which is abundant in the nerve and muscle cells in and around the penis, strips away a nitrogen atom (N) from a passing molecule of the amino acid L-arginine ... and combines it with an atom of oxygen (O)." 27

In other words, by facilitating blood flow to the erectile tissue of the penis, NO produced from L-arginine can give men erections that are bigger, harder, and more frequent. Some men also report that L-arginine gives them greater endurance. "It almost doubled my staying power," said one male enthusiast.

Timing and contraindications

L-arginine users say they can achieve a prosexual effect by taking it 45 minutes before sex. There are few reported side effects. The most notable are:
  • People with herpes—L-arginine may increase the severity of attacks, but some reports indicate that it may also enhance your immune function enough so you are less likely to get herpes attacks. The combination of arginine pyroglutamate and lysine as found in Health Freedom Nutrition’s GH Advantage™ may also reduce this risk.

  • Diabetics and borderline diabetics—L-arginine can raise blood-sugar levels.

Prosexual Nutrients #3 & #4:
CHOLINE & VITAMIN B5
For increased sexual endurance

"I can generally have sex for about twice as long as I can without it," said a man in his 30s who takes vitamin B5.

One woman, who used choline plus vitamin B5, says they help her feel more relaxed during sex. "There's no muscle tightness," she said. "It makes your body feel smoother, especially if you tend to tense up while having an orgasm."

How choline and B5 improve sex

Sexual arousal occurs not just in the genitals but in the whole body, especially in the brain. For men it begins when the brain sends impulses down the spinal cord and out to the nerves that serve the penis. These impulses trigger the production of nitric oxide (NO), which causes penile arteries to dilate and the spongy core of the penis to relax and become engorged with blood.

The neurotransmitter that carries the sexual message from the spinal nerves to the nerves that control the penile arteries and spongy tissue is acetylcholine (ACh).

For women, ACh is also a very important part of sexual function, and its effectiveness in increasing sexual arousal and response has been supported by a number of laboratory studies. For example, Durk Pearson and Sandy Shaw have pointed out that ACh is involved in the build-up toward orgasm and the urethral and vaginal contractions that occur during orgasm as well as the subjective perception of orgasm intensity and duration. 28

Timing and side-effects

Experienced users recommend taking choline plus vitamin B5 or B5 by itself about 20 to 30 minutes before sex to get the full effect right from the start. But, notes one user, "Don't worry if you start too soon, it will kick in as you're going." He adds that pretty much everyone whom he's told about B5, has discovered they have the energy to go longer.

Some people who use choline experience occasional muscle tension headaches, stiff or tight muscles, muscle cramps, and diarrhea. If this happens, you should discontinue use for 1 to 2 days, and resume use of these supplements at a decreased dosage. The GPC form of choline found in Health Freedom Nutrition’s Choline Supreme™ will avoid these systems.

Prosexual Nutrient #5:
GINKGO BILOBA
For enhanced erections and improved mental sharpness

Many research studies have shown ginkgo to be a major aid in improving blood flow through small blood vessels. In one study conducted in Germany, 60 men with "proven arterial erectile dysfunction were asked to take ginkgo biloba extract, 60 mg daily, for 12 to 18 months."

The first signs of improvement were seen after six to eight weeks. After six months, 30 of the 60 men had regained erectile function. In 12 men, papaverine (a vasodialating drug delivered by injection), which had previously been unsuccessful, now worked. Fifteen of the men had improved penile blood flow but still did not respond to papaverine. Only three men had no measurable improvement at all. 29

Many studies also indicated that ginkgo biloba significantly increases mental acuity and memory.

Prosexual Nutrient #6:
TRIBULUS TERRESTRIS
For healthier sperm and increased libido

Tribulus terrestris–—also known as the puncture vine—has been used as a prosexual herb for thousands of years. The ancient Greeks used it as a general health tonic and diuretic. The Chinese used it as a cure for impotence.

Its first reported use in the West was in the 1960's when East European Olympic teams used it to enhance athletic performance and decrease recovery times. 30

More recently, research by the Bulgarian pharmaceutical firm, Sopharma, found that tribulus increased the quality and quantity of sperm production, improved sperm motility and survival, and enhanced libido. 31

100% effective in lab study

The most impressive effects of tribulus terrestris is on sexual libido. In one study, a group of male pigs with "lasting impotence" were tested based on their sexual behavior and sexual movements. The study demonstrated that after a 10-day period, the sexual reflexes were fully recovered in 71% of the animals.

The results were especially astonishing because the animals had suffered "complete absence of libido." By the end of the study, all (100%) of the previously impotent animals had recovered 32 ... the pigs seemed much happier.

How tribulus works

Recent studies of tribulus have verified claims that have been made for hundreds of years. It appears to benefit the cardiovascular system, ease symptoms of angina pectoris and reduce blood pressure. Other studies indicate that it may also be helpful in treating the symptoms of menopause. 33

Tribulus works as an adaptogen, which means that it has a general tonic effect of bringing into balance a variety of hormones and other biochemicals. Tribulus raises testosterone levels when they are low.

According to Ward Dean, M.D., tribulus may be a hypothalamic sensitizer. In other words, it rejuvenates the hypothalamus—the part of the brain that regulates levels of testosterone and many other hormones.

There also appears to be no down side to taking tribulus: You can take it continuously for years and, in addition to improving your sex drive, it will also improve your overall health.

Prosexual Nutrient #7:
YOHIMBE & YOHIMBINE
For heightened libido, increased tactile sensation, multiple orgasms

A 29-year-old video storeowner had this glowing praise of the sexual powers of yohimbe:

"It was the best thing that ever happened. I swear by that. I had longer, thicker, longer-lasting erections and bigger ejaculations, and the feeling that it gives you is incredible."

More than one source we have interviewed mentioned that yohimbe and yohimbine are "tools of the trade" for actors in the X-rated film industry who use them to meet the rigorous demands of their "shooting schedule."

Common reported beneficial effects of yohimbe and yohimbine include heightened libido; increased tactile sensation in the genitals and other parts of the body; longer, harder, larger erections; phenomenal stamina; more powerful orgasms; multiple orgasms and ejaculations; and greater quantities of ejaculate. Yohimbe also helps counteract the sexually depressive effects of medications such as Prozac and other antidepressants.

How yohimbine works

Yohimbe is a natural herbal extract of Corynanthe bark and is available without a prescription by mail order and at health food stores. "yohimbine" is the name for the active ingredient found in yohimbe products.

Yohimbine duplicates a biochemical event believed to play a key role in producing male erection. It inhibits the alpha-2 adrenergic system, increasing the flow of blood through arteries into the penis. It may also result in higher levels of acetylcholine, a neurotransmitter that also facilitates erection.

A recent study also found that yohimbine increases blood levels of the neurotransmitter norepinephrine by 66%—one of the body's natural prosexual chemicals.

One recent study found that yohimbine produced the same overall response rate for both organic and psychogenic impotence, and in fact was as helpful in improving sexual relations as sex therapy and marriage counseling. 34

Safety, side-effects, and contraindications

Yohimbine is one of the safest prosexual nutrients. In one case, a 62-year-old man took 200 milligrams of yohimbine hydrochloride—some 40-times the recommended therapeutic dosage—and had only mild side effects such as rapid heartbeat and temporary hypertension.

However, others have reported such side effects as nausea, anxiety, increased blood pressure, irritability, headache and vomiting.

Yohimbine is not recommended for pregnant women, children, those with kidney problems or with histories of gastric or duodenal ulcer. Geriatric patients should consult with their physician before using yohimbine.

A powerful arsenal for combating sexual dysfunction

Together, the prosexual nutrients discussed here provide a powerful arsenal for combating many forms of sexual dysfunction—including impotence, inability to experience orgasms, lack of sexual desire, and inability to perform.

Each nutrient by itself can improve sexual performance. Working together the results can be truly spectacular: Multiple-orgasms in both men and women ... sex that just lasts and lasts ... long-lasting erections ... and improved overall health and well-being.

Sexual dysfunction may still be the ailment no one wants to talk about. But with the modern arsenal of prosexual nutrients there is no reason for anyone to suffer in silence.

References

  1. Eksplorasi, (a newsletter published by the Indonesian Network for Plant Conservation) Volume 2.4, pg 6.

  2. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam Clin Pharmacol. 2002 Dec;16(6):479-83.
    Abstract

  3. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on libido in middle-aged male rats. J Basic Clin Physiol Pharmacol. 2002;13(3):249-54.
    Abstract

  4. Ang HH, Cheang HS. Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res. 2001 Oct;24(5):437-40.
    Abstract

  5. Ang HH, Ngai TH. Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack. Fundam Clin Pharmacol. 2001 Aug;15(4):265-8.
    Abstract

  6. Ang HH, Cheang HS, Yusof AP. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp Anim. 2000 Jan;49(1):35-8.
    Abstract

  7. Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500.
    Abstract

  8. Ang HH, Sim MK. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res. 1998 Dec;21(6):779-81.
    Abstract

  9. Ang HH, Sim MK. Eurycoma longifolia JACK and orientation activities in sexually experienced male rats. Biol Pharm Bull. 1998 Feb;21(2):153-5.
    Abstract

  10. Ang HH, Sim MK. Eurycoma longifolia Jack enhances libido in sexually experienced male rats. Exp Anim. 1997 Oct;46(4):287-90.
    Abstract

  11. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam Clin Pharmacol. 2002 Dec;16(6):479-83.
    Abstract

  12. Ang HH, Sim MK. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res. 1998 Dec;21(6):779-81.
    Abstract

  13. Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, Riad E, Balansard G, Ohigashi H. In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol. 2002 Sep;82(1):55-8.
    Abstract

  14. Tjahjadi, Riza V "Big Interest In A Small Tree, Bioresearch of Eurycoma longifolia, Pasak Bumi (Eurycoma longifolia) in South East Asia." BioTani Indonesia Foundation/ PAN Indonesia, Issue 6-20, May 18, 2003.

  15. Sexual dysfunction common in men, women. http://Onhealth.webmd.com/conditions/briefs/item2C36836.asp. February 10, 1999.

  16. Morrow D. New means to make men feel younger. The New York Times, March 31, 1998; B1-B2.

  17. Sexual dysfunction: Study sheds lights, HealthOasis, May Clinic online, http://www.mayohealth.org/mayo/9902/htm/sexualdy.htm, Feb 16, 1999.

  18. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 99; 73;1016-25.
    Abstract

  19. Judd HL, Judd GE, Lucas WE, Yen SS. Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Meta. 1974;39:1020-1024.
    Abstract

  20. Adashi EY. The climacteric ovary as a functional gonadotropin-driven androgen-producing gland. Fertil Steril. 1994;62:20-27.
    Abstract

  21. Aleander GM, Sherwin BB. Sex steroids, sexual behavior, and selection attention for erotic stimuli in women using oral contraceptives. Psychoneuroendocrinology, 1993; 18: 91-102.
    Abstract

  22. Bancroft J, Sherwin BB, Alexander GM, Davidson DW, Walker A. Oral contraceptives, androgens, and the sexuality of young women: ii. The role of androgens. Arch Sex Behav. 1991;20:121-135.
    Abstract

  23. Sherwin BB, Gelfand MM. The role of androgen in the maintenance of sexual functioning in oophorectomized women. Psychosom Med. 1987;49:397-409.
    Abstract

  24. Wright, J, M.D. and Lenard L PhD, "Reported Effects of Low Testosterone, Maximize Your Vitality & Potency For Men Over 40, Smart Publications, Petaluma, CA, 1999, p. 225.

  25. Ang HH, Cheang HS, Yusof AP.  Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp Anim. 2000 Jan;49(1):35-8.

  26. Morales AJ, Nolan JJ, Nelson JC, Yen SS. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.   J Clin Endocrinol Metab 1995 Sep;80(9):2799.

  27. Wright, J, M.D. and Lenard L PhD, "Reported Effects of Low Testosterone, Maximize Your Vitality & Potency For Men Over 40, Smart Publications, Petaluma, CA, 1999, p. 74.

  28. Pearson D; Shaw S. The Life Extension Companion. New York: Warner Books, 1984.

  29. Sikora R, Sohn M, Friedrich J, Rohrmann D, Schafer W, Anchlen F. Ginkgo biloba extract in the therapy of erectile dysfunction. J Urol. 1989; 141:188A.

  30. Morgenthaler J, Simms M. The Smart Guide to Better Sex. Smart Publications, Petaluma, CA, 1999. p32.

  31. Ibid.

  32. Op. cit., p32-33.

  33. Op. cit., p33.

  34. Morales A; Condra M; Owen J A; Surridge D H; Fenemore J; Harris C. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol (United States). 139(4): p849-52, Apr 1988.
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