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Natural, Safe, and Better Than Cholesterol Drugs

Drug companies and government agencies are now urging millions more Americans to lower cholesterol with the drugs called "statins." But statins pose risks too frightening to ignore—ranging from high blood sugar and gallstones, to kidney failure and a deadly muscle-wasting disease. Meanwhile, one nutrient outperforms leading statins, and is safe for virtually anyone. Can this remarkable find stop heart disease in its tracks? Read on …

Numerous tests show the natural policosanol preparation: Controls cholesterol as well as—or better than—cholesterol drugs Has no side effects, zero risks—even at "mega" doses Stimulates your body's own "cholesterol flush"—for lifetime prevention Protects post-menopausal women, even when diet fails Protects elderly from heart disease Fights high cholesterol in diabetics—where cholesterol drugs pose risks Makes artery cells stronger, healthier, and resistant to plaque Slashes risk of deadly clots throughout your entire body Relieves muscle pain caused by poor circulation

It’s never too late to protect and rejuvenate your heart health. One of the most effective things you can do—right now—is to lower your cholesterol.

Even small changes mean a big difference for your health and longevity: every 10% drop in cholesterol lowers your risk of heart attack by 25%.1 That's a difference that can save lives. In fact, lowering cholesterol is now proven to be a key to living a longer, more energetic life.2

Thanks to the wildly popular cholesterol drugs known as "statins," it's easier than ever to control cholesterol. Only problem is, it may be more dangerous than ever.

Millions of statin prescriptions are written every year, for about $60 to $120 per month. The statins, also known as "HMG-CoA reductase inhibitors," include Lipator, Baycol, Crestor, Lescol, Mevacor, Pravachol, and Zocor. They work by blocking the production of cholesterol in the liver itself, which lowers LDL (the "bad") cholesterol and slightly raises HDL (the "good") cholesterol.

But here's the problem:

The very same medications designed to protect and support a long, healthy life are now proven to pose potentially life-threatening risks.

What's worse, some of the so-called top-tier statins fail to fend off a heart attack, stroke, or death ... while others may actually increase hidden risks to your heart.

But there is a way to get the protective benefits of lower cholesterol, without the risks of prescription cholesterol-lowering drugs.

You can erase dangerous cholesterol from your bloodstream, naturally.

And, you can avoid the frightening side effects of cholesterol drugs.

One nutrient works wonders for your cholesterol and heart health, without risk. Health-conscious individuals of all ages are taking it with excellent results. That includes post-menopausal women, the elderly with inherited high cholesterol, men and women with existing heart disease, those who suffer angina (chest pain), those with leg cramps, diabetics, and even those who just want to maintain healthy cholesterol levels and promote higher energy.

Get safe, fast results: Lower LDL 29% … Lower total cholesterol 21% Increase healthy HDL by 15% or more

This nutrient also strengthens your arteries, and—amazingly—it promotes your body's natural cholesterol-lowering ability for a lifetime of protection and rejuvenation. Studies show it can even reverse the progression of artery and heart disease.3,4

HEART HEALTH FACT #1: Heart disease is the number one killer of men and women over 40. HEART HEALTH FACT #2: One in two Americans has high cholesterol—a prime cause of hardened, narrowed arteries, which leads to heart disease, heart attack, and stroke. HEART HEALTH FACT #3: Leading cholesterol drugs are linked to new and FRIGHTENING side effects, disease, and death. HEART HEALTH FACT #4: One surprising alternative lowers dangerous cholesterol up to 29% … risk-free.

In numerous scientifically controlled studies, this single nutrient has outperformed leading cholesterol drugs, and has been proven to be completely free of the toxic dangers caused by the statins. Anyone who takes cholesterol drugs or who is about to start should know about this well-documented alternative.

It's available now … and it's never been more urgent. Especially today, when researchers and international medical journals are asking:

1. Are statins really safe enough for long-term use?
2. Can you really "live with" the side effects?
3. Do statin drugs really reduce your risk of death?
   

In 2002, the American College of Cardiology, the American Heart Association, and the National Heart, Lung and Blood Institute warned doctors about a disturbing risk caused by statins. That risk is a toxic, potentially deadly, muscle disorder called Rhabdomyolysis.

But by the time that warning came, it was already too late for untold numbers of statin users. In August 2001, the cholesterol drug Baycol®, made by Bayer Pharmaceutical, was withdrawn from the market after it was linked to 40 deaths. In January 2002, Baycol was officially linked to an additional 100 deaths.5 Crestor® has also been directly linked to this muscle-wasting disease.6 Scientific reviews conclude that all statins carry this risk.7

For some, muscle pain and toxicity can happen rapidly. For others it may take months or years to build up in the body, leaving a trail of clues your doctor may not recognize—including muscle and joint pains, muscle weakness, and an increase in a chemical called creatine kinase, which often indicates future kidney failure, heart damage, and death.8

Another cholesterol drug called Zocor® (Simvastatin), may increase risks to your heart. Zocor saps your body of very important antioxidants and nutrients, including CoQ10 which is heart-protective. In fact, congestive heart failure patients typically have low levels of CoQ10.9 Zocor has also been shown to increase blood sugar levels by 13% which increases risk for insulin-resistance and Type II diabetes. And, as recently reported at the European Society of Cardiology, Zocor fails to prevent heart attack, stroke, hospital readmission, and death in heart patients who've had angioplasty.10

Drug companies caught red-handed

Cholesterol drug manufacturers such as Merck, AstraZenica and Pfizer earned $26 billion worldwide last year, even as evidence continued to mount against the statins.

• Statins offer little or NO protection for women without heart disease from heart attack, heart disease "events," or death.11
  
  
• Statins may reduce risk of heart attack in the elderly, but they may fail to protect against stroke, and can cause new cases of cancer.12
  
  
• Statins can cause liver damage or liver failure. You're at greater risk if you have other diseases such as diabetes or kidney failure, if you're taking other medications, or if you've recently had surgery. Other high risk groups include the elderly and those who drink heavily.
  

You don’t have to take these risks and ... you can bring those numbers down safely

Heart disease is the leading cause of death for men and women over 40. By retirement age, a staggering 65 percent of Americans will have some form of cardiovascular disease. This year alone, 1.1 million Americans will suffer a heart attack, and 600,000 will suffer a stroke.13

One in two Americans has high cholesterol.14 Total cholesterol levels of 200 mg/Dl or higher put you in the danger zone. The sooner you get that number under control, the better.

But … and here is the most important message of this article … you want that cholesterol reading to come down for the right reasons.

You want to control your cholesterol in a way that gives you more energy, vitality, real protection, and anti-aging benefits

That's why I'm thrilled to tell you about policosanol. Policosanol is the generic name for a highly concentrated and standardized mixture of five natural alcohols that occur together in sugar cane wax (Saccharum officinarum).

This unique and remarkable substance represents a major heart-health breakthrough. It costs far less than dangerous statins, and it lowers your cholesterol to heart-healthy levels, safely.

You see, statins work by inhibiting a liver enzyme called HMG CoA reductase. This is the enzyme that enables the liver to make cholesterol. When you take a drug to block that enzyme, the liver is forced to take cholesterol from your bloodstream in order to meet your body's daily needs for cholesterol. That brings down blood cholesterol levels.

However, it appears be to the potent enzyme-blocking action that causes serious risks, especially in the high doses often recommended.

Policosanol, on the other hand, has been shown to regulate the production of the cholesterol enzyme to lower, healthier levels, without directly blocking it.15,16 Policosanol also enhances your body's own natural ability to remove and process dangerous LDL cholesterol from the blood and cells.17,18

Can the safe, natural solution stop heart disease in its tracks?

Extensive research demonstrates that taking 5-20 mg daily of policosanol improves ALL cholesterol readings: total cholesterol, low-density lipoprotein (LDL—the "bad"), high-density lipoprotein (HDL—the "good"), cholesterol ratios, and triglycerides.21-32

A medical review of policosanol studies published in peer-reviewed journals concluded these impressive results: At doses of 10 to 20 mg per day, policosanol lowers LDL cholesterol by 21% to 29%, raises heart-protective HDL cholesterol by 8% to 15%, and reduces total cholesterol by 17% to 21%.33

And policosanol is safe.

While statins become increasingly toxic with higher doses, policosanol achieves maximum effect at very low doses. Remarkably, higher doses are neither more effective nor dangerous.

In fact, policosanol has undergone unusually extensive testing to prove its safety. In lab studies, doses up to 1,500 times the normal human dose (on the basis of body weight) have shown no negative effects.34-38

NOTE: Even in small doses, policosanol significantly increases HDL cholesterol, versus statins, which have little or no effect on HDL.39 That improved HDL number means …

Policosanol kicks your body's natural cholesterol-flush into action

Policosanol appears to be the most thorough and effective way to get protection and lower serious risks—for virtually anyone, of any age.

• Excellent results for post-menopausal women: In one study, post-menopausal women with high cholesterol went on a 6-week cholesterol-lowering diet—but cholesterol wouldn't budge.
  At 5 mg of policosanol daily, after 8 weeks, LDL came down 17.3%. The dose was then increased to 10 mg daily. After another 8 weeks, LDL came down 26.7%. At 8 and 16 weeks, total cholesterol was down 12.9% and 19.5%, respectively, and ratios of LDL to HDL cholesterol were down 17.2% and 26.5% respectively. At 16 weeks, total HDL was up 7.4%.40 Other studies confirm the remarkable results, including one in which HDL cholesterol came up an impressive 29.3%.41
  
  
• Urgent support for elderly with inherited high cholesterol: Inherited high cholesterol (which starts at birth), can result in heart attacks even at a very early age. In one study, 179 older patients went on a cholesterol-lowering diet, and then were given either a placebo or policosanol at 5 mg daily for 12 weeks, followed by 10 mg daily for another 12 weeks. The results: policosanol, at 5 and 10 mg, lowered LDL by 16.9% and 24.4%, respectively; reduced total cholesterol by 12.8% and 16.2%; and increased HDL by 14.6% and 29.1%. Policosanol, but not the placebo, significantly improved overall cardiovascular health and stamina in these patients, and there were no adverse side effects.42 Numerous studies confirm the results.43,44
  
  
• Beats Lovastatin for diabetics with high cholesterol: Type II (adult onset) diabetics have an increased risk of high cholesterol and cardiovascular disease. In a 12-week study of 53 Type II diabetics comparing 10 mg per day of policosanol versus Lovastatin at 20 mg per day, policosanol lowered LDL cholesterol 20.4% … versus 16.8% by Lovastatin. Policosanol lowered the ratio of LDL-cholesterol to HDL-cholesterol 23.7% … versus 14.9% by lovastatin. Policosanol also caused a greater increase in HDL-cholesterol.45 NOTE on safety for diabetics: There is NO viable carbohydrate value to policosanol.
  
  
• Policosanol users "win" the stress test: The treadmill stress test is an important measurement of your aerobic capacity—how well your body can take in oxygen under stress. In one study, 45 heart patients took 10 mg of policosanol, policosanol plus aspirin, or a placebo plus aspirin. The study lasted 20 months. Both policosanol groups experienced relief from chest pain, better energy and endurance, and fewer "cardiac events." Tests showed an overall increase in maximum oxygen uptake and aerobic capacity in policosanol groups.46
  
  
• Relieves leg cramps, with long-term results: Policosanol relieves the pain of intermittent claudication (peripheral arterial disease), a potentially disabling condition that causes attacks of pain or fatigue in the calf, thigh or buttock. When 62 patients took 20 mg of policosanol or a placebo daily for 6 months, the policosanol group had fewer painful attacks and greater ongoing relief—with no side effects.47 A follow-up 2-year study showed that the relief doesn't wear off, but improves with time. So do the heart-protective effects.48
  
  
• Support for those with high blood pressure and high cholesterol: In a 12 month study of 589 elderly men and women with high cholesterol and high blood pressure but no history of heart disease, policosanol improved all cholesterol ratios, and reduced blood pressure. It also slashed risk of vascular and "all cause events" by more than 60%.49

Across the board, policosanol can go head to head with the statins. It has performed better than or equal to Simvastatin, Pravastatin, Lovastatin, Probucol, and Acipimox.50 In one revealing study, policosanol outperformed not one, but two top-tier cholesterol-lowering drugs. Just 10 mg of policosanol reduced LDL 24% compared with 22% for Lovastatin (Mevacor) at 20 mg, and 15% for Simvastatin (Zocor) at 10 mg.51

IMPORTANT: Artery disease is a multi-step process which responds favorably to multiple layers of protection and prevention. What makes policosanol truly exceptional for heart health is that it delivers benefits beyond lowering cholesterol:

• Reverse "toxic" LDL cholesterol and dangerous inflammation: LDL cholesterol poses the greatest threat to your arteries when it becomes oxidized. Oxidized LDL causes inflammation, destroys blood vessels, and creates serious plaque formation. Policosanol blocks this dangerous process.52,53
  
  
• "Forever young" healthy heart and arteries: You want your arteries to be lined with a smooth layer of cells that allows healthy, unobstructed blood flow. Policosanol reduces dangerous cell growth that leads to thick, overgrown artery walls.54
  
  
• Prevents harmful "sticky blood"—often better than cholesterol-drugs.55,56
  
  
• Protects arteries by preventing scarring and lesions—often better than statins.57,58

Policosanol is available in a proprietary, new formula designed to lower high cholesterol and stimulate maximum artery-cleansing and heart-protective benefits. We've spent a lot of time and effort searching for the very best product available and are proud to recommend it. Beware of policosanol "imposter" formulas that fail to deliver real heart-protective results. There are a few different forms of policosanol out there, including those made from rice and beeswax. But the results from the clinical trials were obtained using ONLY the policosanol derived from sugar cane wax.

Across the board, policosanol can go head to head with the statins. It has performed better than or equal to Simvastatin, Pravastatin, Lovastatin, Probucol, and Acipimox.50 In one revealing study, policosanol outperformed not one, but two top-tier cholesterol-lowering drugs.

You won't find this high-quality product on the shelf of your natural foods store. And you won't find another safe, natural product that has the amazing success rate of policosanol. The formula is called Choletrol™ by Health Freedom Nutrition.

Choletrol may well be the most important thing you can do for your heart health and longevity.

Remember, heart disease is America's number one killer. The older you are, the more serious your risk. If you're over 40, we don't want you to take any chances at all.

This new policosanol-based formula is a powerhouse for your heart and more

Choletrol protects against a lesser-known, but highly toxic substance called homocysteine. Studies conducted over the last 25 years consistently link high levels of the amino acid homocysteine with an increased risk of heart disease, heart attack, and stroke. Your body produces homocysteine as a normal by-product of eating protein—specifically meat and dairy products. At toxic levels homocysteine creates a dangerous chemical reaction that hardens and clogs arteries. Once homocysteine is produced, your body can convert it back to safe substances or substances that can be flushed easily from the body, with the aid of adequate levels of B vitamins: B6, B12, and folic acid. One group of scientists suggests that up to 25,000 deaths a year in the US could be prevented by fortifying foods with folic acid alone.59 And extensive research confirms the link between B vitamin supplements and lower homocysteine levels.60-62 In one controlled study of over 1,500 subjects, homocysteine levels dropped to normal as blood levels of folic acid, B12, and B6 rose. Those who take formulas containing these nutrients also appear to enjoy substantial protection from vascular disease.63

Choletrol also includes IHN (inositol hexanicotinate.) IHN is a compound of niacin (B3) and inositol (another B vitamin) that delivers the substantial heart and circulation benefits of regular niacin—but NOT the flushing and itching. IHN improves circulation by relaxing arteries and veins. It improves blood flow to the brain to relieve tinnitus (or ringing in the ear); to the extremities to combat Reynaud's Disease; and to the legs to relieve calf cramping. Lab research also shows it can lower total cholesterol by a whopping 79.5%, and lower triglycerides by 63.2%.64

Choletrol also includes an Asian herb used successfully to reverse heart and artery conditions. It's called Notoginseng. This little-known species of the herb ginseng improves blood flow to the heart muscle by cleansing the blood and relaxing the coronary artery.65 It also lowers artery pressure and improves circulation in and around damaged heart tissue.66 Notoginseng also boosts overall circulation to the brain as well as the heart, and harmonizes the nervous system, cardiovascular system, and immune system. Notoginseng is richer in active factors, called saponins, than its two more popular ginseng cousins, Panax and American Ginseng, and it's an extremely powerful antioxidant. We recommend it highly, especially as part of the complete Choletrol formula.

These exceptional nutrients target the most urgent and serious threats to your heart health, and they are safe to take every day.

We recommend Choletrol with complete confidence. You won't find a safer, more effective and reliable way to promote healthy cholesterol levels and lower your risk of heart disease.

References

1. www.loweringcholesterol.net/show/lower-ldl-cholesterol
   
   
2. www.americanheart.org/presenter.jhtml?identifyer=4524
   
   
3. Janikula M. Policosanol: A new treatment for cardiovascular disease? Altern Med Rev 2002 Jun;7(3):203-17.
   Abstract
   
   
4. Gouni-Berthold I, Berthold HK. Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 2002 Feb;143(2):356-65.
   Abstract
   
   
5. www.msnbc.com/news/690373.asp
   
   
6. www.citizen.org/pressroom/release.cfm?ID=1657
   
   
7. MA Omar, JP Wilson, and TS Cox, "Rhabdomyolysis and HMG-CoA reductase inhibitors" Ann. Pharmacother., Sep 2001; 35:1096 - 1107.
   
   
8. Stephen G. Ellis, MD; Derek Chew, MBBS; etal. Death Following Creatine Kinase-MB Elevation After Coronary Intervention. American Heart Association, Inc. Published online before print August 19, 2002, doi:10.1161/01.CIR.0000028146.71416.2E
   Abstract
   
   
9. Alternative Medicine Guide: Heart Disease, Stroke & High Blood Pressure, Future Medicine Publishing, Tiburon, California, 1998. 31-32.
   
   
10. http://heartdisease.about.com/b/a/109906.htm
    
    
11. Judith M. E. Walsh, MD, MPH; Michael Pignone, MD, MPH. Drug Treatment of Hypelipidemia in Women. JAMA. 2004;291:2243-2252.
    
    
12. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002 Nov 23;360(9346):1623-30.
    Abstract
    
    
13. http://www.laskerfoundation.org/reports/html/heartdisease.html
    
    
14. www.americanheart.org/presenter.jhtml?identifyer=4506
    
    
15. Menendez R, Amor AM, Rodeiro I, et al, Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Arc Med Res 2001 Jan-Feb;32(1):8-12.
    Abstract
    
    
16. Menendez R, Amor AM, Gonzalez RM, Fraga V, Mas R. Effect of Policosanol on the hepatic cholesterol biosynthesis of normocholesterolemic rats. Biol Res 1996;29(2):253-7.
    Abstract
    
    
17. Gouni-Berthold I, Berthold HK. Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 2002 Feb;143(2):356-65.
    Abstract
    
    
18. Menendez R. Fernandez SI, Del Rio A, et al, Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res. 1994;27(3-4):199-203.
    Abstract
    
    
19. Batista J, Stusser R, Saez F, Perez B. Effect of Policosanol on hyperlipidemia and coronary heart disease in middle-aged patients. A 14-month pilot study. "… a clinical tendency to improve their CHD, in comparison with the placebo group." Int J Clin Pharmacol Ther 1996 Mar;34(3):134-7.
    Abstract
    
    
20. 3. Janikula M. Policosanol: A new treatment for cardiovascular disease? Altern Med Rev 2002 Jun;7(3):203-17.
    Abstract
    
    
21. Mirkin A, Mas R, Martinto M, Boccanera R, Robertis A, Poudes R, Fuster A, Lastreto E, Yanez M, Irico G, McCook B, Farre A. Efficacy and tolerability of Policosanol in hypercholesterolemic post-menopausal women. Int J Clin Pharmacol Res 2001;21(1):31-41.
    Abstract
    
    
22. Janikula M. Policosanol: a new treatment for cardiovascular disease? Altern Med Rev 2002 Jun;7(3):203-17.
    Abstract
    
    
23. Gouni-Berthold I, Berthold HK. Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 2002 Feb;143(2):356-65.
    Abstract
    
    
24. Castano G, Mas R, Fernandez JC, Illnait J, Fernandez L, Alvarez E. Effects of Policosanol in older patients with type II hypercholesterolemia and high coronary risk. J Gerontol A Biol Sci Med Sci 2001 Mar;56(3):M186-92.
    Abstract
    
    
25. Castano G, Mas R, Fernandez JC, Fernandez L, Illnait J, Lopez Effects of Policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs R D 2002;3(3):159-72.
    Abstract
    
    
26. Pons P, Rodriguez M, Robaina C, Illnait J, Mas R, Fernandez L, Fernandez JC. Effects of successive dose increases of Policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. Int J Clin Pharmacol Res 1994;14(1):27-33.
    Abstract
    
    
27. Crespo N, Illnait J, Mas R, Fernandez L, Fernandez J, Castano G. Comparative study of the efficacy and tolerability of Policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. Int J Clin Pharmacol Res 1999;19(4):117-27.
    Abstract
    
    
28. Prat H, Roman O, Pino E. Comparative effects of Policosanol and two HMG-CoA reductase inhibitors on type II hypercholesterolemia [Article in Spanish] Rev Med Chil 1999 Mar;127(3):286-94.
    Abstract
    
    
29. Mas R, Castano G, Illnait J, Fernandez L, Fernandez J, Aleman C, Pontigas V, Lescay M. Effects of Policosanol in patients with type II hypercholesterolemia and additional coronary risk factors. Clin Pharmacol Ther 1999 Apr;65(4):439-47.
    Abstract
    
    
30. Canetti M, Moreira M, Mas R, Illnait J, Fernandez L, Fernandez J, Diaz E, Castano G. A two-year study on the efficacy and tolerability of Policosanol in patients with type II hyperlipoproteinaemia. Int J Clin Pharmacol Res 1995;15(4):159-65.
    Abstract
    
    
31. Pons P, Rodriguez M, Robaina C, Illnait J, Mas R, Fernandez L, Fernandez JC. Effects of successive dose increases of Policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. Int J Clin Pharmacol Res 1994;14(1):27-33.
    Abstract
    
    
32. Arruzazabala ML, Molina V, Mas R, Fernandez L, Carbajal D, Valdes S, Castano G Antiplatelet effects of Policosanol (20 and 40 mg/day) in healthy volunteers and dyslipidaemic patients. Clin Exp Pharmacol Physiol 2002 Oct;29(10):891-7.
    Abstract
    
    
33. Gouni-Berthold I, Berthold HK. Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 2002 Feb;143(2):356-65.
    Abstract
    
    
34. Aleman CL, Puig MN, Elias EC, Ortega CH, Guerra IR, Ferreiro RM, Brinis F.Carcinogenicity of Policosanol in mice: an 18-month study. Food Chem Toxicol 1995 Jul;33(7):573-8.
    Abstract
    
    
35. Aleman CL, Mas Ferreiro R, Noa Puig M, Rodeiro Guerra I, Hernandez Ortega C, Capote A. Carcinogenicity of Policosanol in Sprague Dawley rats: a 24 month study. Teratog Carcinog Mutagen 1994;14(5):239-49.
    Abstract
    
    
36. Janikula M. Policosanol: a new treatment for cardiovascular disease? Altern Med Rev 2002 Jun;7(3):203-17.
    Abstract
    
    
37. Rodriguez MD, Garcia H. Evaluation of peri- and post-natal toxicity of Policosanol in rats. Teratog Carcinog Mutagen 1998;18(1):1-7.
    Abstract
    
    
38. Rodriguez MD, Garcia H. Teratogenic and reproductive studies of Policosanol in the rat and rabbit. Teratog Carcinog Mutagen 1994;14(3):107-13.
    Abstract
    
    
39. Castano G, Mas R, Fernandez L, Illnait J, Mesa M, Alvarez E, Lezcay M."Comparison of the Efficacy and Tolerability of Policosanol with Atorvastatin in Elderly Patients with Type II Hypercholesterolaemia." Drugs Aging 2003;20(2):153-63.
    Abstract
    
    
40. Mirkin A, Mas R, Martinto M, Bocconera R, Robertis A, Poudes R, Fuster A, Lastreto E, Yanez M, Irico G, McCook B, Farre A. Efficacy and tolerability of Policosanol in hypercholesterolemic post-menopausal women. Int J Clin Pharmacol Res 2001;21(1):31-41.
    Abstract
    
    
41. Castano G, Mas R, Fernandez L, Fernandez JC, Illnait J, Lopez LE, Alvarez E. "Effects of Policosanol on postmenopausal women with type II hypercholesterolemia. Gynecol Endocrinol 2000 Jun;14(3):187-95.
    Abstract
    
    
42. Castano G, Mas R, Fernandez JC, Illnait J, Fernandez L, Alvarez E. Effects of Policosanol in older patients with type II hypercholesterolaemia and high coronary risk. J Gerontol A Biol Sci Med Sci 2001 Mar;56(3):M186-92.
    Abstract
    
    
43. Pons P, Rodriguez M, Robaina C, Illnait J, Mas R, Fernandez L, Fernandez JC. Effects of successive dose increases of Policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. Int J Clin Pharmacol Res 1994;14(1):27-33.
    Abstract
    
    
44. Castano G, Mas R, Fernandez L, Illnait J, Lopez E. Effects of Policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs R D 2002;3(3):159-72.
    Abstract
    
    
45. Crespo N, Illnait J, Mas R, Fernandez L, Fernandez J, Castano G. Comparative study of the efficacy and tolerability of Policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. Int J Clin Pharmacol Res 1999;19(4):117-27.
    Abstract
    
    
46. Stusser R, Batista J, Padron R, Sosa F, Pereztol O. Long-term therapy with Policosanol improves treadmill exercise-ECG testing performance of coronary heart disease patients. Int J Clin Pharmacol Ther 1998 Sep;36(9):469-73.
    Abstract
    
    
47. Castano G., Mas R. A double-blind, placebo-controlled study of the effects of Policosanol in patients with intermittent claudication. Angiology 1999 Feb;50(2):123-30.
    Abstract
    
    
48. Castano G, Mas Ferreiro R, Fernandez L, Gamez R, Illnait J, Fernandez C. A long-term study of Policosanol in the treatment of intermittent claudication. Angiology 2001 Feb;52(2):115-25.
    Abstract
    
    
49. Castano G, Mas R, Fernandez JC, Fernandez L, Illnait J, Lopez E. Effects of Policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs R D 2002;3(3):159-72.
    Abstract
    
    
50. Janikula M. Policosanol: A new treatment for cardiovascular disease? Altern Med Rev 2002 Jun;7(3):203-17.
    Abstract
    
    
51. Prat H., Roman O. Comparative effects of Policosanol and two HMG-CoA reductase inhibitors on type II hypercholesterolemia. Rev Med Chil 1999 Mar;127(3):286-94.
    Abstract
    
    
52. Menendez R, Mas R, Amor AM, Gonzalez RM, Fernandez JC, Rodeiro I, Zayas M, Jimenez S. Effects of Policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. Br J Clin Pharmacol 2000 Sep;50(3):255-62.
    Abstract
    
    
53. Fraga V, Menendez R, Amor AM, Gonzalez RM, Jimenez S, Mas R. Effect of Policosanol on in vitro and in vivo rat liver microsomal lipid peroxidation. Arch Med Res 1997 Autumn;28(3):355-60.
    Abstract
    
    
54. Gouni-Berthold I, Berthold HK. Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 2002 Feb;143(2):356-65.
    Abstract
    
    
55. Castano G, Mas R, Arruzazabala ML, Noa M, Illnait J, Fernandez JC, Molina V, Menendez A.Effects of Policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. Int J Clin Pharmacol Res 1999;19(4):105-16.
    Abstract
    
    
56. Arruzazabala ML, Mas R, Molina V, Carbajal D, Mendoza S, Fernandez L, Valdes S. Effect of Policosanol on platelet aggregation in type II hypercholesterolemic patients. Int J Tissue React 1998;20(4):119-24.
    Abstract
    
    
57. Noa M, Mas R, Mesa R. A comparative study of Policosanol vs lovastatin on intimal thickening in rabbit cuffed carotid artery. Pharmacol Res 2001 Jan;43(1):31-7.
    Abstract
    
    
58. Noa M, Mas R. Effect of Policosanol on lipofundin-induced atherosclerotic lesions in rats. J Pharm Pharmacol 1995 Apr;47(4):289-91.
    Abstract
    
    
59. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995; 274:1049-57.
    Abstract
    
    
60. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocystinemia in humans. J Nutr. 1994; 124:1927-33.
    
    
61. Chait A, Malinow MR, Nevin DN, Morris CD, Eastgard RL, Kris-Etherton P, Pi-Sunyer FX, Oparil S, Resnick LM, et al. Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease. Am J Clin Nutr. 1999; 70(5):881-7.
    Abstract
    
    
62. Arnadottir, M., Brattistrom, O., Simonsen, H, et al, The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine co in dialysis patients, Clin Nephrol, 1993, 40:236-240.
    
    
63. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, Palma-Reis RJ, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997; 277(22):1775-81.
    Abstract
    
    
64. El-Enein AMA, Hafez YS, Salem H, Abdel M. The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents. Nutr Reports Int 1983;28:899-911.
    
    
65. Lei XL, Chiou GC. Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza. Am J Chin Med. 1986; 14(3-4): 145-52.
    Abstract
    
    
66. Teeguarden, Ron. Radiant Health: The Ancient Wisdom of the Chinese Tonic Herbs. Warner Books, NY, 1998, pp. 171-173.