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Clarifying the Complex World of Nutrition Science

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Revitalize Your Circulatory System, Brain and Body with Ginkgo Biloba

1) Safety: Watch Out for Ginkolic Acid!

Most people aren't aware that Ginkgo leaves contain a toxic compound, ginkgolic acid. Pharmaceutical-grade Ginkgo extract must contain 24% flavonoids, 6% triterpenes, and less than 5 parts per million of ginkgolic acid. But in the US, you can't be sure how much ginkgolic acid is in your product unless it is specifically stated on the label … and most manufacturers don't list it on the label. (And the sad fact is that many Ginkgo products contain more - much more ginkgolic acid than is considered safe.)

Know what to look for

Even if the ingredients aren't on the label, it's important to learn what makes a Ginkgo biloba extract safe and effective … so you can intelligently ask manufacturers about their product and know what you're buying!

Standard Ginkgo biloba products contain 24% flavonoids and 6% triterpenes, but the label usually doesn't tell you anything about the levels of toxic ginkgolic acid.

Although Ginkgo extract must meet the standard described above, plus contain less than 5 ppm of ginkgolic acid in order to be sold as a pharmaceutical in Europe, there has been no such quality control in the US dietary supplement market. This is a major concern for consumers because Ginkgo produced for pharmaceutical use and rejected because it exceeds the 5 ppm ginkgolic acid level is often sold as a dietary supplement at inexpensive prices to unknowing consumers.

After all, supplements are not a grocery item! There is a difference in quality and, as we've seen, sometimes a difference in safety too. Even with something like vitamin E that might seem like just another commodity item … there is a wide spectrum of grades of vitamin E available to the nutritional supplement manufacturer. A synthetic vitamin E supplement (dl-alpha tocopherol) will be less expensive than a natural vitamin E supplement (d-alpha-tocopherol), but won't be as bioavailable or effective.

Play it safe

Originally, scientists issued warnings that ginkgolic acid levels have to be controlled because it was found to be an allergen that can cause severe allergic reactions in certain people. We also now know that ginkgolic acid damages DNA (a risk for cancer development) and is toxic to nerve cells and the immune system.10

In one study, mice were injected with ginkgolic acid and had significant immunological reactions that appeared in the lymph nodes. The researchers concluded that every care should be taken to guarantee the most complete removal of these compounds as possible during the extraction process. 11

In fact, to the contrary, one independent examination of Ginkgo products showed that some contained THOUSANDS of times the pharmaceutical quality limit of less than 5 ppm ginkgolic acid! 12

It is important to not take Ginkgo products that don't meet the standard of less than 5 ppm Ginkgolic acid (5 parts of Ginkgolic acid per million)!

2) Effectiveness: Make Sure Your Ginkgo has a High Bilobalide Content to Get All the Benefits

New studies have shown that bilobalide, a unique phytochemical that is found only in Ginkgo, may prove to be one of the most significant breakthroughs in brain anti-aging. Bilobalide is a substance that recent research has shown to:

  • Induce important brain growth factors
  • Prevent cell death from amyloid protein—a culprit in Alzheimer's disease
  • Protect mitochondria, the tiny energy factories inside cells that provide the "spark of life"
  • Protect against Alzheimer's and other neurodegenerative disorders
  • Prolong life span
  • Work synergistically with the other compounds in Ginkgo

Buying a high-quality Ginkgo supplement that contains at least 3% bilobalide is very important, since the latest research shows bilobalide to be one of the major active components of the extract.13 But most companies don't tell you the amount that's in their product.

How long should I take Ginkgo biloba extract?

Ginkgo biloba extract will continue to boost your brain power and circulation for as long as you take it. One bottle is a great start. You'll notice almost immediately that your thinking is sharper, your memory is clearer, and you have more brain power to do the things you want to do with confidence.

Recent findings that life long Ginkgo supplementation not only preserves memory, but also prevents the deterioration of the energy producing mitochondria in cells and extends the life span of animals makes taking Ginkgo every day a logical choice. The only choice.

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Editor's Note:

The natural health solutions described in this article are available through many on-line retailers including those listed below. By clicking these links you help support the important alternative health research we provide.

Visit www.amazon.com – a great way to find competitive deals on supplements offered by many different manufacturers.

Visit www.hfn-usa.com – when commitment to quality and freshness is important, this factory direct solution is preferred by many of our readers.

This article is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.

References

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  2. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Ahlemeyer B, Krieglstein J. Institute for Pharmacology und Toxicology, Department of Pharmacy, Philipps University of Marburg, Ketzerbach 63, 35032 Germany. Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S8-14. 

  3. Thiagarajan G, Chandani S, Harinarayana Rao S, Samuni AM, Chandrasekaran K, Balasubramanian D. "Molecular and cellular assessment of ginkgo biloba extract as a possible ophthalmic drug." Mol Biol (Noisy-le-grand) 2002 Sep;48(6):593-9 

    Fies P, Dienel A. "Ginkgo extract in impaired vision--treatment with special extract EGb 761 of impaired vision due to dry senile macular degeneration." Wien Med Wochenschr 2002;152(15-16):423-6 

  4. Jezova D, Duncko R, Lassanova M, Kriska M, Moncek F. "Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers."J Physiol Pharmacol 2002 Sep;53(3):337-48.

  5. Gohil K, Moy RK, Farzin S, Maguire JJ, Packer L. "mRNA Expression Profile of a Human Cancer Cell Line in Response to Ginkgo Biloba Extract: Induction of Antioxidant Response and the Golgi System." Free Radic Res 2000 Dec;33(6):831-849

  6. Le Bars PL, Velasco FM, Ferguson JM, Dessain EC, Kieser M, Hoerr R. "Influence of the severity of cognitive impairment on the effect of the Ginkgo biloba extract EGb 761 in Alzheimer's disease" Neuropsychobiology 2002;45(1):19-26

  7. Stough C, Clarke J, Lloyd J, Nathan PJ. "Neuropsychological changes after 30-day Ginkgo biloba administration in healthy participants." Int J Neuropsychopharmacol 2001 Jun;4(2):131-4

  8. Kennedy DO, Scholey AB, Wesnes KA. "The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers." Psychopharmacology (Berl) 2000 Sep;151(4):416-23.

  9. Yoshikawa T, Naito Y, Kondo M. "Ginkgo biloba leaf extract: review of biological actions and clinical applications." Antioxid Redox Signal 1999 Winter;1(4):469-80

  10. Westendorf J, Regan J. Induction of DNA strand-breaks in primary rat hepatocytes by ginkgolic acids. Pharmazie. 2000 Nov;55(11):864-5.

  11. Koch E, Jaggy H, Chatterjee SS. Evidence for immunotoxic effects of crude Ginkgo biloba L. leaf extracts using the popliteal lymph node assay in the mouse. Int J Immunopharmacol. 2000 Mar;22(3):229-36. 
    Abstract


    Baron-Ruppert G, Luepke NP. Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET).Phytomedicine. 2001 Mar;8(2):133-8.

  12. Kressmann S, Muller WE, Blume HH. Pharmaceutical quality of different Ginkgo biloba brands. J Pharm Pharmacol 2002 May;54(5):661-9 

  13. Defeudis FV. Bilobalide and neuroprotection. Pharmacol Res2002 Dec;46(6):565-8.