Smart Publications

Clarifying the Complex World of Nutrition Science

  • Email this article
  • Print this article
  • A
  • A
  • A

Oral Chelation: Magnesium-EDTA Versus Calcium Disodium-EDTA

Recently I received a very nice looking brochure in the mail about heart disease. As an advocate of oral chelation I was intrigued, so I browsed through the brochure with interest. While turning the first couple of pages my confidence grew as I read about the history of EDTA and its beneficial effect on heart health. But when I got to the section about magnesium EDTA, I was horrified!

It's unheard of that educated medical doctors would recommend the ingestion of magnesium EDTA! In fact, Dr. Garry Gordon, father of modern chelation therapy says, "I can find no research on using magnesium EDTA for oral chelation."

Why am I so concerned? The term EDTA chelation is used quite loosely, and refers to the intravenous and/or oral use of EDTA chelates for binding heavy metals and excreting them from the body.

The most common forms of EDTA are calcium and sodium chelates, which are available in both USP (United States pharmacopoeia) and FCC (food chemical codex) forms. Magnesium EDTA, however, is not available in either of these standards. In fact, magnesium EDTA is manufactured commercially for use in plant fertilizers. Has magnesium EDTA been proven safe for human consumption? NO, it hasn't!

Even after 68 years of research into EDTA chemistry, the calcium disodium form continues to come out on top in regards to lowest toxicity, longest history of safe use in humans and other animals, and as the safest and most effective oral chelator.

One of the reasons I was especially concerned about this advertisement is that all of the positive studies using the calcium disodium form of EDTA are quoted; it even makes the correct assertion that EDTA has a low toxicity level when compared to aspirin. But then the ad switches gears by recommending magnesium EDTA and making negative statements about the proven EDTA compounds. Simply deceptive!

The brochure raises the question that since chelation removes excess blood calcium that contributes to artery-clogging plaque, why include calcium in a product designed to remove calcium? Well—other than the obvious issues relating to 38 years of safe and beneficial oral chelation—calcium disodium EDTA works on calcified deposits, not calcium directly.

This calcification is a conglomeration of calcium and heavy metals and is not soluble or metabolized due, in part, to its heavy metal content. As calcium disodium EDTA encounters these calcifications, it chelates the heavy metal portion of these deposits allowing the release of the calcium for use in normal metabolic functions.

Magnesium EDTA removes essential calcium from cells

On the other hand, weak chelates like magnesium have a high affinity for calcium, and this can remove too much calcium too quickly from cells and damage or kill them. This is a problem of stronger not necessarily being better. Weak chelates of EDTA have a stronger affinity for calcium than calcium disodium EDTA. But this makes those weak chelates more toxic by removing ESSENTIAL calcium from cells. And we certainly don't want to remove essential calcium from cells that need it to live.

Only EDTA in the form of calcium-sodium will not remove essential calcium — but will remove the unwanted calcifications that promote atherosclerosis.

I believe magnesium EDTA is being used as an advertising gimmick, as it has no place in a dietary supplement.

See These Articles of Interest From
Smart Publications Health & Wellness Update

EDTA Chelation: The Most Effective Treatment for Preventing Cardiovascular Disease ... Just Got a Surprising New Explanation for its Effectiveness

Q&A with Dr. Garry Gordon (On EDTA Oral Chelation) 

Editor's Note:

The natural health solutions described in these article are available through many on-line retailers including those listed below. By clicking these links you help support the important alternative health research we provide.

Visit NutriStand – The Nutrition Newsstand from the Supplement Man for Science-Based Nutritional Supplements!

Visit International Antiaging-Systems for hard to find therapies. They specialize in Tomorrow's Treatments Today™.

Visit – a great way to find competitive deals on supplements offered by many different manufacturers.

Visit VitaE8 - The Ultimate Vitamin E – to learn more about the importance of full-spectrum vitamin E supplements.

These articles are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.


Thank you for clarifying the difference between the two forms of EDTA. Everything gets so confusing sometimes. You made it easy.

why do you suppose the company cardio renew and the other company wonderlabs both sell edta sodium and disodium based not calcium disodium, yet they both claim their product is effective, and they have been around for awhile. Do you think that only calcium disodium is to be used orally for cleansing, not their product. Thanks for anyhelp. S

Somewhere I saw claims made that Magnesium Dipotassoum EDTA is better than either Didsodium or Calcium Disodium EDTA.

What can be said about it?

If you really like him, then you should tell him before it is too late. When he goes to college, he is going to see a lot of girls there. Once he finds a good one, then you might miss him forever. how to speed up my computer

Leave a Comment

Commenting is not available in this channel entry.