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Nattokinase—The Natural Blood Thinner

How important is healthy blood circulation to you?

The significance of proper blood circulation can not be over emphasized. The ability of your heart to pump blood throughout your body efficiently and effectively is the cornerstone of good health.

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Unfortunately, there are forces at work that interfere with your heart’s ability to effectively move blood through your veins and arteries.
Some of these forces are natural extensions of the aging process. Others are genetic predispositions that have been passed down through generations. And, of course, others are risk factors that we created through our own unhealthy habits that leave us susceptible to cardiovascular disease (CVD).

Whatever the reason, mainstream healthcare has banded together with the pharmaceutical industry to offer a temporary quick fix for CVD, today’s number one killer. They have developed statin drugs to reduce cholesterol. They promote aspirin and warfarin to thin the blood. They provide anti-hypertension medications to reduce blood pressure and offer bypass surgery and angioplasty to clear the arteries. Essentially, these all help prolong the life of a patient with cardiovascular disease. But none of these drugs or procedures is without risk or side effects. So what do we do?

You can greatly reduce the risk of cardiovascular disease by modifying your lifestyle and adding nutritional supplements proven to support cardiovascular health. Research has shown that oral EDTA chelation is extremely effective in removing toxic heavy metals from the blood stream. And there are new studies showing that vitamin K2 can prevent arterial calcification. And of course, eating a lighter, more balanced diet, quitting tobacco and exercising regularly will go a long way towards heading off most cases of heart disease and stroke before they ever happen.

But, can you do more? Yes, there is something else you can do to ensure your circulatory system is operating optimally. But before we get to that, we’d like to first mention …

A word about blood clots

Blood clotting is a natural process that allows our blood to thicken and form a clot or thrombus of blood cells. When a blood vessel is injured, platelets clump together and strands of the blood protein fibrin glue them together in order to stop the bleeding. Eventually the clot helps form a protective scab over a healing wound. If our bodies did not have the ability to clot blood, we would bleed to death after even a minor cut, which was often the case with hemophiliacs before the development of pharmaceutical blood clotting agents.

But sometimes blood clots form even when you have not been wounded or cut. Although most blood clots naturally dissolve on their own without complications, there are two situations in which they can wreak havoc before they are reabsorbed by your body.

1) A thrombus (blood clot) can form in an artery and block the flow of blood which cuts off oxygen supply. This can trigger a heart attack and result in damage, destruction (infarction), or even death of the tissues (necrosis) in the heart. In the brain, blood clots also block blood and oxygen from reaching necessary areas, which can result in senility and/or stroke.1

2) A piece of the blood clot could form in one of the heart’s chambers and then travel through the bloodstream, lodging in either an organ or an artery and cutting off the blood supply from that point, causing an embolism. An embolism is especially dangerous when it ends up in your lung, as it can result in a sudden lack of respiratory function.

The most common cause of these emboli is blood clots that form during atrial fibrillation. This is a disorder found in about 2 million Americans. In atrial fibrillation the heart’s two small upper chambers (the atria) quiver instead of beating effectively. Some blood isn’t pumped completely out of them when the heart beats, so it pools and clots. When a blood clot enters the circulation and lodges in a narrowed artery of the brain, a stroke occurs.

The chances of developing thrombi increase as we age

Although our human body produces several enzymes for making blood clots, it produces only one enzyme—plasmin—for dissolving them. The problem is, as we age the production of plasmin is reduced, making blood more prone to coagulation and clotting.

To make matters worse, fibrinogen (a blood clotting protein) levels rise as we get older.2 And high levels of fibrinogen usually lead to increased platelet aggregation, blood clots, and eventually heart attack or stroke. In fact, high fibrinogen levels are considered a more dangerous risk factor for heart attack and stroke than high cholesterol. A study of 2,116 men found that those with high LDL (bad) cholesterol but low fibrinogen levels had only one sixth the risk for heart attack than the men with low LDL and high fibrinogen.3

So preventing blood clots, particularly in older individuals, is a crucial step in preventing heart attack and stroke. And if you can do this naturally, without expensive pharmaceuticals and their nasty side effects, why not start now?

Nattokinase – the natural blood thinner

Natural nutritional support for normal, healthy blood flow and circulation can be found in the enzyme Nattokinase. Nattokinase has been shown to support normal blood pressure, dissolve blood clots and prevent them from forming in the first place! 

What is Nattokinase?

Nattokinase is a potent fibrinolytic (anti-clotting) enzyme extracted and highly purified from a traditional Japanese food called Natto. Natto is a fermented cheese-like food that has been used in Japanese culture for more than 1,000 years and as a folk remedy for heart and vascular diseases. Research has shown that Nattokinase supports the body’s ability to break up and dissolve the unhealthy coagulation of blood. In fact, it has been shown to have four times greater fibrinolytic activity than plasmin—the body’s primary anti-clotting enzyme.4

How is Nattokinase made?

Natto is produced in a fermentation process by adding the bacteria Bacillus subtilis to boiled soybeans. The resulting Nattokinase enzyme is produced when Bacillus subtilis acts on the soybeans. While other soy foods contain enzymes, it is only the Natto preparation that contains the specific Nattokinase enzyme.

How was Nattokinase discovered?

Japanese researcher Dr. Hiroyuki Sumi had spent many years searching for a natural thrombolytic agent that could successfully dissolve blood clots associated with heart attacks and stroke. Finally in 1980, after testing more than 173 natural foods, Sumi found what he was looking for.

Some traditional Natto was dropped onto artificial thrombus (blood clot) in a petri dish and allowed to stand at 37 degrees C (approximately body temperature)—and over the next 18 hours, the thrombus around the Natto completely dissolved! Sumi named the newly discovered protease enzyme Nattokinase, which means “enzyme in Natto.” Dr. Sumi remarked that Nattokinase showed “a potency matched by no other enzyme.”5

How does Nattokinase work?

Nattokinase enhances our body’s natural ability to fight blood clots, and has an advantage over blood thinners because it has a prolonged effect without side effects. Nattokinase:

  • Supports normal blood pressure
  • Prevents blood clots from forming
  • Dissolves existing blood clots
  • Dissolves fibrin
  • Enhances the body’s production of plasmin and other clot-dissolving agents, including urokinase (an enzyme produced by the kidneys and found in the urine, which activates plasminogen)

Research studies

Nattokinase has been the subject of numerous scientific studies, including two small human trials. In 1990, Dr. Sumi’s research team published a series of studies demonstrating the fibrinolytic effects of Nattokinase.7 Here are some of the research highlights:

Nattokinase dissolves blood clots

Researchers from JCR Pharmaceuticals, Oklahoma State University, and Miyazaki Medical College tested Nattokinase on 12 healthy Japanese volunteers (6 men and 6 women, between the ages of 21 and 55). The researchers gave the volunteers 7 ounces of Natto (the food) before breakfast, and then tracked fibrinolytic activity through a series of blood plasma tests. 

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Editor's Note:

The natural health solutions described in this article are available through many on-line retailers including those listed below. By clicking these links you help support the important alternative health research we provide.

Visit International Antiaging-Systems for hard to find therapies. They specialize in Tomorrow's Treatments Today™.

Visit – a great way to find competitive deals on supplements offered by many different manufacturers.

Visit VitaE8 - The Ultimate Vitamin E – to learn more about the importance of full-spectrum vitamin E supplements.

This article is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.


  1. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002.

  2. Heinrich, J. et al. Fibrinogen and factor VII in the prediction of coronary risk. Arterioscler Thromb 1994, 14:54-59.

  3. Sumi H. Interview With Doctor of Medicine Hiroyuki Sumi. Japan Bio Science Laboratory Co. Ltd.

  4. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4.

  5. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002.

  6. Sumi, H. et al. “Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase.” Acta haematol 1990, 84: 139-43.

  7. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull 1995 Oct;18(10):1387-91.

  8. Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98.

  9. Maruyama M, Sumi H. Effect of Natto Diet on Blood Pressure. JTTAS, 1995.

  10. Nishimura, K. et al. Natto diet was apparently effective in a case of incipient central retinal vein occlusion. Japan Rev Clin Ophthalmol 1994, 88:1381-85.

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I am now on 6 and 7 mgs of warfarin, can I change to nato, and how.Had 2 minor strokes in June and July. Am 76 yrs old. had angeogram earlier and arteries are completely clear

I am 57 years old and have been taking warfarin 10 mg a day for 2 years. I cant take many of the supplements I used to take because of the warfarin. I would like to get off it.I was told by my hemotogogist that I needed to stay on warfarin indefinately because I have 2 hereditary blod clotting factors.. I had a DVT 2 years ago which started all this.
If I were to switch to Nattokinase how would I be able to regulate the proper dosage? Would I be tested periodically for blood clotting levels if I am not on Warfarin? I am afraid my doctors know nothing about these supplement alternatives.
Thank you for your reply.
Rachel Roang

I would like to see the answers to the above comments which naturally apply to myself.

I agree with Rachel Roang above, that doctors know nothing about Nattokinase. How about nutritionists, would they be able to guide one onto Natto from warfarin safely?

I have been on Warfarin for over five years due to a mechanical heart valve. I tend to be resistent to blood thinners so I must take 15 mg a day.  I have found that vitamin E suppliments have great thinning properties.  After just a few days, my blood is significantly thinner. Not so with other ‘natural’ thinners.

is it safe and advisable to alternate plavix and nattokinase.

I have essential thrombocytopenia and is on hydroxyurea and anagrelide. How can i alternate Nattokinase?

Go to

Any Doctor that doesn’t use natural meds is not worth his weight in dog dung.

my dr.wants to start me on blood thinners they only use drugs i don,t like drugs because s. affects can i take one cap per day of nattokinase?thank you Ross.

Hello Doctor Gordan!
My name is Yelena.My sister had stroke 2 years ago. She has Antiphospholipid Syndrom. Can she use Nattokinase suplemant to thin blood and refuse to take warfarin?
  Thank you very much!

I would like to see your replies to these comments.

I am on Warfarn 5MG for Atril Fib. I now have a pacemaker Defibulator. Can I switch to Nattokinase? How would I make the transition?

For those who are looking to move toward natural solutions like Nattokinase, we applaud you.  However, you must check with a knowledgeable doctor before discontinuing your current medications.  The information we provide is not a substitute for a doctor’s recommendation.

For those who want to go a step further, please visit the Health Advisor section of our website.

yes i,m using nattokinase.

I would also like to know your comments to the above questions I want to get off coumadin and have been told about nattakonaise as an alternative.

I would like to know your commets to the above questions please.

For obvious legal reasons, I can’t advise people on discontinuing any drug that is being prescribed by your doctor.

What I can suggest, however, is that you go to the following page on our site where you’ll find a very sophisticated tool called Solutions Health Advisor. It is free, yet very powerful, and may help guide you:

You can also read my interview with Dr. Joseph Pizzorno, who developed this tool, here:

Will Nattokinase replace Coubidin with no problems and how do you know how much to take

How can I measure my protime during my transition to an all nattokinase treatment for a-fib?

Which is the best way to take Nattokinase, as Natto or as an enzyme and which brand do you recommend?

Have read a lot about Nattokinase,where can I order this item

Thanks for this teaching Holy spirit may the enemie of my soul be rebuked forevermore come this where it may pertain me come lower casing God and not Glorifying him….. in Jesus name…....  Terrill T.C. Thanks Again!  T.C

Thank you for your post. Really looking forward to read more. Cool. ebook

As noted above, I had a stroke in June of 2010 and another in July of 2010. I was put on Coumadin and took for, I don’t know, 9 or 10 months, but made up my mind I was going to get off of it, with or without my Dr.‘s say. When talking to a doctor about nattokinase, you may as well talk to your cat. There is no way they wanted me to get off Coumadin, so I just stopped taking it and went to Natto 4 times a day to make sure I was getting enough,  did this for a couple of months, then dropped back to 3 times a day for a couple of months, until today I’m down to taking it 2 times a day, which is what I will stay at. The strength I take is 2000 FU {100mg}  Best move I ever made, as I now eat anything I want and don’t have any worries about doing so.

Thanks for sharing, Great post festa peppa

I have been taking Vasculex from You can replace Warfarin with this. The inventor of this is a heart doctor. I asked my doctor about it and they couldn’t criticize, just said there aren’t enough case studies. It is derived from Natto.

WIll taking Nattokinase raise my INR to the level desired by my doctor?


When taking Natto your INR is no longer relevant, so you wont even have to take it anymore.

I used Warfarin to kill rats on the farm 60 years ago. I saw whatnit did! I took myself OFF Warfarin about 18 months ago and am doing fine on Natto. Look for Dr. David Williams and Dr. Sinatra. I get mine from Williams. BK.

Thank you for the comment from Howard Beck man above but, respectfully. Angel Jackets

There are many paleo snack ideas available, but all that remains is for one to decide on which ones best suit his/her diet. The snacks can be delicious, but at the same time they need to be healthy.! paleo snack ideas

You have done a great job. I will definitely dig it and personally recommend to my friends. I am confident they will be benefited from this site.

Took me time to read all the comments, but I really enjoyed the article. It proved to be Very helpful to me and I am sure to all the commenters here! It’s always nice when you can not only be informed, but also entertained!

I found this info amazing! almost 3 years ago (Feb 3 2012) I was put into the hospital until March 2, 2012 with a severe DVT in my Femoral Artery branching into my Iliac… mi d you was was 8months pregnant so this was a very scary and frightful even for me and my family. At the time I was 24 I couldn’t imagine something g so terrible happening to me! it was awful. Turns out I have Factor V (5) Leiden, a genetic blood clotting disorder. I was on Lovenox and then branched to Coumadin for over 6 months! I begged and begged my hematologic to take me off warfarin. Finally I came across an article that told me about Nattokinase and I was so excited! Finally a natural medicine I can take to help with my problem. I asked my doctor about it and although he is I western medicine he sees benefits of natural medicine which I was so glad that he approved me to be o. the natto!

I heard this recently from my family doctor, he also recommend me the similar procedure as you mentioned above.

I thought it was going to be some boring old post, but it really compensated for my time. I will post a link to this page on my blog. I am sure my visitors will find that very useful. dentist craiova

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