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Nattokinase: Powerful Enzyme Prevents Heart Attack and Stroke

Nattokinase: Powerful Enzyme Prevents Heart Attack and Stroke

Cardiovascular disease is the leading cause of death for men and women

According to the U.S. Centers for Disease Control, each year about 700,000 people suffer a stroke, the leading cause of serious, long-term disability in the United States. The American Heart Association estimates that nearly every year, about 1 million Americans will suffer a heart attack.

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About 700,000 of these will be first-time heart attack sufferers, while approximately 500,000 will be people who have previously had a heart attack. It all adds up to this: contrary to popular belief, heart attack and stroke account for more deaths than all cancers and injuries combined, and one out of every 2.4 deaths is attributable to cardiovascular disease. How is that possible in the richest, most highly educated country on earth?

Most of us all get too little exercise, accumulate too much stress, and eat a poor diet laden with saturated fat, refined sugar and too little fiber. Add to that list the habit of smoking and the answer is quite clear. (Although there is a considerably higher prevalence of cigarette smoking in Japan than in the U.S., mortality from CVD among men in Japan is still less than half of that in the U.S.3) And to make matters worse, a study published in The Journal of the American Medical Association (3/6/2002) indicates that exposure to air pollution can cause some 10,000 fatal heart attacks a year in the U.S.!

Mainstream health care has banded together with the pharmaceutical industry to offer a temporary quick fix for the number one killer of our time. Statin drugs reduce cholesterol. Aspirin and warfarin thin the blood. Anti-hypertension medications reduce blood pressure. Bypass surgery, and angioplasty clear the arteries. Essentially, they all help prolong the life of a patient with cardiovascular disease (CVD). But none of these drugs or procedures is without risk or side effects. Well, we've got good news for you!

CVD risk can be greatly reduced by modifying lifestyle and adding nutritional supplements proven to support cardiovascular health. Most of us are aware that eating a lighter, more balanced diet, quitting tobacco and exercising regularly are enough to head off most cases of heart disease before they ever happen. Now there's something else you can do.

Nattokinase has been shown to support normal blood pressure, dissolve blood clots and prevent them from forming in the first place!

What Is Nattokinase?

Nattokinase is a potent fibrinolytic (anti-clotting) enzyme complex extracted and highly purified from a traditional Japanese food called Natto. Natto is a fermented cheese-like food that has been used in Japanese culture for more than 1,000 years for its popular taste, and as a folk remedy for heart and vascular diseases. Research has shown that Nattokinase supports the body in breaking up and dissolving the unhealthy coagulation of blood. In fact, it has been shown to have four times greater fibrinolytic activity than plasmin.4

How is it made?

Natto is produced by a fermentation process by adding the bacteria Bacillus subtilis to boiled soybeans. The resulting Nattokinase enzyme is produced when Bacillus subtilis acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific Nattokinase enzyme. How was Nattokinase discovered? Japanese researcher Dr. Hiroyuki Sumi had spent many years searching for a natural thrombolytic agent that could successfully dissolve blood clots associated with heart attacks and stroke. Finally in 1980, after testing more than 173 natural foods, Sumi found what he was looking for.

Natto, a traditional Japanese soy cheese, was dropped onto an artificial thrombus (fibrin) in a petri dish and allowed to stand at 37ºC (approximately body temperature). Over the next 18 hours, the thrombus around the natto completely dissolved! Sumi named the newly discovered enzyme Nattokinase, which means "enzyme in natto." Dr. Sumi remarked that Nattokinase showed "a potency matched by no other enzyme." 56

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This article is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.

References

  1. Soy intake shown to reduce mortality rate from cancer and CVD. Nagata C. Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. Int J Epidemiol. 2000 Oct;29(5):832-6. 

  2. Fujita M, Nomura K, Hong K, Ito Y, Asada A, Nishimuro S. Biochem Biophys Res Commun 1993 Dec 30;197(3):1340-7 Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan. 

  3. Clinical trials.gov. Epidemiology of Coronary Heart Disease in Men Aged 40 and Over. August 2004. National Institutes of Health. Sept. 13, 2004. 

  4. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. 

  5. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002. 

  6. Hager, K. et al. Fibrinogen and Aging. Aging (Milano) 1994, 6:133-38.

  7. Heinrich, J. et al. Fibrinogen and factor VII in the prediction of coronary risk. Arterioscler Thromb 1994, 14:54-59. 

  8. Sumi H. Interview With Doctor of Medicine Hiroyuki Sumi. Japan Bio Science Laboratory Co. Ltd. 

  9. Sumi, H. et al. "Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase." Acta haematol 1990, 84: 139-43.

  10. Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98.

  11.  Maruyama M, Sumi H. Effect of Natto Diet on Blood Pressure.JTTAS, 1995.

  12. Nishimura, K. et al. Natto diet was apparently effective in a case of incipient central retinal vein occlusion. Japan Rev Clin Ophthalmol1994, 88:1381-85.

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36 Comments

Thank you for your informative article. What is a safe daily amount of Nattokinase taken as a dietary supplement? Thanks for your time and attention. JJA

I have read that one capsule of nattokinase supplying 2000fu activity can have a positive impact on hypertension and that it is safe to take three per day.  I would suggest anyone with a bleeding disorder should proceed with caution by starting with one capsule per day for a week or two and then increase as needed.  The same approach would be prudent for those taking blood thinning or anti-platelet drugs.

I am 69 and have been treated for essential thrombocytosis for 5 years.  I recently developed serious side effects from Hydrea and was switched to Anagrelide (.5 mg twice daily).

I have taken Nattokinase before and loved how I felt. My platelets also were reduced slightly.  I also have taken the combination Nattokinase and Serrapeptase and thought it was exceptionally good.

Do you have any experience with ET or the treatment with Nattokinase and/or Serrapeptase for ET?

Thank you so much.

Is it safe to take Curamin which contains nattokinase when taking 1 baby aspirin and two omega 3 every day.  I was taken off cumadin and told to take aspirin and omega 3 instead and now am trying curamin for pmr.

Common blood thinner increases risk of bone fracture

Elderly patients taking the commonly prescribed blood thinner warfarin experience an increased risk for osteoporosis-linked bone fractures, according to a study at Washington University School of Medicine in St. Louis.

“We did a retrospective study of Medicare records for about 15,000 patients hospitalized with atrial fibrillation, and we identified fractures related to osteoporosis,” says lead author Brian Gage, M.D., associate professor of medicine and medical director of Barnes-Jewish Hospital’s Blood Thinner Clinic. “Our analysis showed that long-term use of warfarin—longer than one year—led to a 25 percent increase in the incidence of fracture.”

http://www.eurekalert.org/pub_releases/2006-01/wuso-cbt012306.php

My cat scan showed there is vascular caldcification involving the abdominal aorta.  There is intramural thrombus with areas of plaque ulceration.  My doctor cannot give me aspirin or Plavix since I have an ulcer.  I was told about Nattokinase and was told to take 2 capsules daily.  Should I take only 1 and will this interfer with my uler.  Thank You.

“December 2nd, 2010 at 6:28am by Joan Reichert:
My cat scan showed there is vascular calcification involving the abdominal aorta.  There is intramural thrombus with areas of plaque ulceration.  My doctor cannot give me aspirin or Plavix since I have an ulcer.  I was told about Nattokinase and was told to take 2 capsules daily.  Should I take only 1 and will this interfer with my ulcer.  Thank You.”


Here is some information I found to be useful. Isn’t it interesting that the very thing used to prevent blood clots can also induce calcification? I cannot recommend what dose of Natto you should take because: a) I am not a doctor and b) I do not know what other medications you are using, etc., but there are some good suggestions in some of the links below.


Can Anything Cure Vascular Calcification?
Vitamin K’s Role in Stopping and Reversing Calcification
Oct 5, 2009 Sarah Tomley


For many years the build-up of calcium in the body was thought to be irreversible, but new research has shown that vitamin K may be able to stop the process.

Vascular calcification can occur as an effect of ageing or disease, such as kidney disease or diabetes, or it can occur as a consequence of blood-thinning treatment, such as warfarin. For many years the build-up of calcium in the body was thought to be an irreversible process, but new research has shown that the calcification is an actively regulated process, so it may be preventable or even reversible.

Why Does Calcium Build Up in the Blood Vessels and Tissues?
The probable cause of vascular calcification is still being investigated, but it appears that two proteins – matrix Gla (MGP) and osteopontin (OPN) – play a part.

Researchers have been able to study the process by altering the levels of these proteins within rats, causing fairly rapid death simply by depriving them completely of MGP. Scientists have also deliberately induced calcification in rats by feeding them high levels of warfarin, the blood-thinning drug, in order to test a possible cure.


The Blood-thinning Connection
One study, by the Cardiovascular Research Institute (CARIM) and VitaK, Maastricht University in 2007 (1) found that high-dose vitamin K not only blocked new arterial calcium build-up due to warfarin, but also reduced existing levels.

The vitamin K treatment only worked at high doses. Four groups of rats were subjected to warfarin, then three groups were taken off the drug. Those on no vitamin K or low-dose vitamin K continued to suffer from rising levels of calcification, but those on high-dose vitamin K treatment saw calcification decrease by over 37 per cent within only 6 weeks. The vitamin actually reversed the process.

In another study of 4,500 elderly patients, scientists established an inverse relationship between dietary intake of menaquinone (synthetic vitamin K) and aortic calcification, myocardial infarction, and sudden cardiovascular death. (2)

Interestingly, experiments using samples of healthy and diseased aorta have shown high tissue concentration of vitamin K2 in the heathy aorta, but no K1; and no K1 or K2 in the samples of diseased aorta.

How Does Vitamin K Stop Calcification?
Matrix Gla protein (MGP) is a protein that prevents vascular calcification – and it is only activated in the presence of vitamin K. (MGP must be carboxylated to become active, and vitamin K is a cofactor for carboxylation.) There is so much calcium and phosphate circulating in the body, that without the inhibiting action of MGP, calcification occurs after around six weeks.

As anticoagulant drugs such as warfarin interfere with vitamin K, they block MGP function, and so induce calcification.

Should I Take Vitamin K Supplements?
Research suggest that menaquinone-7 (MK-7) has a much longer serum half-life than phylloquinone (vitamin K1) or MK-4, with better bioavailability. This means that regular nutritional doses (50–150ug/da) may lead to accumulation levels in the circulation and tissues that would only be reached with far higher doses of K1 or MK-4. (5) The best source of natural vitamin K2 is Natto, a Japanese fermented food. Other forms of fermented food such as cheeses and curd also contain MK-7, but in much lower quantities. Green leafy vegetables – such as kale, lettuce, spinach and broccoli – contain the highest content of K1, and account for most of the Western intake of this vitamin, followed by vegetable oils, such as soybean, olive oil and canola.

Meat, fish, dairy products and eggs contain both K1 and MK-4; this is especially concentrated in butter, egg yolk, and goose liver. (6)

In Western diets K1 makes up around 80 per cent of vitamin K intake, although research suggests that at least 50 percent should be K2, and that supplementation of MK-7 may be desirable. One study found that a pharmacological dose of K1 (1mg/day for 3 years, co-administered with minerals and vitamin D) had beneficial effects on the elastic properties of the arterial vessel wall.

http://www.suite101.com/content/can-anything-cure-vascular-calcification-a155895

Nattokinase - Fermented Trouble?
“Nattokinase seems to be orally available when administered to humans. Taking enteric-coated nattokinase capsules 1.3 grams three times daily seems to significantly increase measures of fibrinolytic activity for 2 to 8 hours. Acta Haematol 1990;84:139-143
http://www.ptinr.com/data/templates/default.aspx?a=190&template=print-article.htm

Twinlab products make a Vit-K liquid supplement.

Now foods offers Nattokinase (nowfoods.com)

Both can either be purchased (or special ordered) at most health food stores.

Write again if you have any other questions or comments!

Thank you for responding, but you did not mention about the blood clot and if it would dissolve it?  Thank you.

Natto is supposed to dissolve blood clots. Here is an excerpt from another study:

According to Dr. Milner, what makes nattokinase a particularly potent treatment is that it bolsters the body’s natural abilities to fight blood clots in several different ways. It closely resembles plasmin and dissolves fibrin directly. In addition, it also enhances the body’s production of both plasmin and other natural clot-dissolving agents, including urokinase.

In some ways, he says, nattokinase is actually superior to conventional clot-dissolving drugs. T-PAs like urokinase are only effective when taken intravenously and often fail simply because a stroke or heart attack victim’s arteries have hardened beyond the point where they can be treated by any clot-dissolving agent. Nattokinase, however, can help prevent that hardening with an oral dose of as little as 100 mg a day.

http://www.healthsavers.info/savealife_files/ProdMoreInfo/Nattok-HSI-MoreInfo.htm

from the angiogram, i have 60 % blockages but do not need bypass or angioplasty as further testd results based on stress tests with thilium x ray, the blood flow is ok . one reason is becos i have lots of collaterals being a keen squash player. now on cardiprin (aspirin) , crestor and approval to control borderline hypertension. )natto helps with blood clots but is this same as plagues in arteries?? i very keen to start natto but please advise as i am on also on cardiprin.  ( if need more specifics, let me know so that i can get from medical records tqvm.

I’m not a doctor, but I’ve dealt with blood clots and am now using Natto for the past three months without incident (or ANY other drugs).

If I were in your shoes I probably wouldn’t take statins (crestor) because they use up Co-Q 10.

I’d be more focused on trying to reduce the inflammation in my arteries.

Something is causing it. Read the following links and see if any of these are useful.

Crestor-side effects
http://www.spacedoc.net/crestor.htm

The new plaque busters
http://www.usatoday.com/news/health/2003-11-23-plaque-usat_x.htm

Prevent and REVERSE heart disease
http://www.heartattackproof.com/articles.htm

The last link is from a Physician at the Cleveland Clinic. He was an athlete like yourself and has a son who is a fire fighter and follows his plant based diet.

Question: What is the cause of the disease?
Answer: It is the typical western diet of processed oils, dairy, and meat which destroys the lifejacket of our blood vessels known as our endothelial cells. This cell layer is a one cell thick lining of all of our blood vessels. Endothelial cells manufacture a magical protective molecule of gas called nitric oxide, which protects our blood vessels. It keeps our blood flowing smoothly, it is the strongest dilator (widener), of our blood vessels, it inhibits the formation of blockages (plaques), and t inhibits inflammation.
Question: With such natural protection why do we ever develop heart disease?
Answer: Every western meal of processed vegetable oils, dairy products, and meat (including chicken and fish) injures these endothelial cells. As individuals consume theses damaging products throughout their lives, they have fewer functioning endothelial cells remaining and thus less of the protective nitric oxide. Without enough nitric oxide the plaque blockages build up and grow creating eventually heart disease and strokes.
Question: Can it be stopped or even reversed?
Answer: Yes…..........

Had a pulmonary embolism-put on coumodin-could natto kinase be used instead???

“February 4th, 2011 at 11:58am by tony wyatt
Had a pulmonary embolism-put on coumodin-could natto kinase be used instead???”


Your question is too general to be specific and I am not a doctor, but for the sake of this forum, here is some info that might be useful anyway.

“Nattokinase shouldn’t be used by people with bleeding disorders, or by people who are taking “Coumadin (warfarin), aspirin, or any other drug that influences blood clotting (unless under doctor’s supervision).”

altmedicine.about.com/od/nattokinase/p/nattokinase.htm


“Fibrinogen is a protein in your blood that helps blood clot. Too much fibrinogen can cause a clot to form in an artery, leading to a heart attack or stroke.”

Direct Labs (http://www.directlabs.com) allows you to get tests without having to go through a doctor. They offer a test that can measure fibrogen levels. Very worthy test to see if your body is dissolving the clots.

Heart Health Panel
Only $ 129

Includes: Lipid Profile,
C-Reactive Protein hs, Fibrinogen & Homocysteine “

What a wonderful and complete article.  Thank you,

I am on Pradaxa for arrhythmia and would like to know if I can take natto with it or replace Pradaxa

“March 17th, 2011 at 2:10pm by Robert
I am on Pradaxa for arrhythmia and would like to know if I can take natto with it or replace Pradaxa”

Why take Pradaxa at all? Its another blood thinner. Did you read all the side effects that Coumadin, Warfarin cause? Excess bleeding, Osteroporosis?

The other two CAUSE new problems. That is why people are using Natto instead.

Before you quit taking it, Ask your doctor what the side effects are of Pradaxa. See if they are the same as the other two and you might have your answer.

Also, drinking soda raises your risk of stroke by more than 50%.

http://www.naturalnews.com/031398_diet_soda_stroke.html

Find the cause of what is causing your health issue so you don’t have to take stuff that adds to your list of meds.

I had a DVT from my ankle to my hip. The calf has cleared out but the femoral area clot won’t budge. It’s been 6 months and I have been on Coumadin since I was diagnosed. I would love to take Natto, would it work even if the clot is 6 months old? Do I talk to my doc to get off Coumadin first?

I have arthrosclerosis in my legs. I am not taking aspirin or any other medication for it since the specialist tells me there is no cure. My Naturopath Dr. has suggested Nattokinase. I have read all the available info. on it but can find little regarding arthrosclerosis.
Any advice?

Thank you

“March 22nd, 2011 at 2:08pm by cathie
I had a DVT from my ankle to my hip. The calf has cleared out but the femoral area clot won’t budge. It’s been 6 months and I have been on Coumadin since I was diagnosed. I would love to take Natto, would it work even if the clot is 6 months old? Do I talk to my doc to get off Coumadin first?”

I had bi-lateral pulmonary clots in both lungs. Also had them in my legs at different times.

I’ve been taking Natto for about 6 months and haven’t had an incident since, so I think its working. If I felt I had a clot left that weren’t budging, I’d up my intake of Natto to more than the 4 caps a day I’m taking now. So far what I’m using seems to be preventing new ‘problems’. Keeping my fingers crossed!

If your nervous about not taking Coumadin then try the Natto with it first and let your doctor know what your doing. Hopefully you have a doctor that has an open enough mind to cooperate and keep testing your INR until you have taken Natto long enough to see results. Show him the article about how it dissolves clots in the lab.

You might also copy the link above about blood thinners causing osteoporosis, print this and give it to him. Tell him you hope to eventually get off the Coumadin entirely would like to be able to take Natto alone.

I know my doctor would read me the riot act if he knew I had quit Warfarin and am only taking the Natto. But its my life and I have to live it. Hopefully this natural ‘alternative’ to rat poison will be what I need to prevent my body from producing anymore clots.

Good luck!

Someone wrote that they are taking Pradaxa for arrhythmia (irregular/abnormal heart rhythm). This is a newer blood thinner that works like coumadin or warfarin. When taking blood thinners, you are instructed to minimize your use of Vit K.

Please read the link below and ask yourself how helpful it is to have to take a med that can CAUSE osteoporosis or stroke, yet is unable to dissolve existing clots or eliminate the cause of abnormal clotting. 

The Missing Nutrient to Blame for Heart Attacks and Osteoporosis (Nope - NOT Calcium or Vitamin D)
By Dr. Mercola

The past decade has brought an explosion of research revealing the many beneficial roles vitamin D plays in keeping you healthy.

But there’s a new kid on the block that could end up being “the next vitamin D,” and we are finding that some of vitamin D’s benefits are greatly enhanced when combined with this other vitamin.

That “new kid” is vitamin K.

Much new research is now focusing on the synergy between vitamin K (specifically, vitamin K2) and vitamin D3, particularly in terms of bone strength and cardiovascular health.

Vitamin K Basics

Vitamin K may very well end up being as important for you as vitamin D, as research continues to illuminate the growing list of its benefits for your health. Vitamin K is probably where vitamin D was ten years ago, with respect to its appreciation as a vital nutrient that has far more advantages than originally thought.

And, according to Dr. Cees Vermeer, one of the world’s top researchers into vitamin K, nearly everyone is deficient in it—just like most people are deficient in vitamin D.

Most of you get enough K from your diet to maintain adequate blood clotting, but NOT enough to offer protection against the following health problems—and the list continues to grow:

Arterial calcification, cardiovascular disease and varicose veins
Brain health problems, including dementia (the specifics of which are under study)
Osteoporosis   Tooth decay
Prostate cancer, lung cancer, liver cancer and leukemia
Infectious diseases such as pneumonia

Vitamin K exists in two basic forms, K1 and K2:

Vitamin K1: Found in green vegetables, K1 goes directly to your liver and helps you maintain a healthy blood clotting system. (This is the kind of K that infants need to help prevent a serious bleeding disorder.)

Vitamin K2: Bacteria produce this type of vitamin K. It is present in high quantities in your gut, but unfortunately is not absorbed from there and passes out in your stool. K2 goes straight to vessel walls, bones, and tissues other than your liver.

Making a long story even longer, there are several different forms of vitamin K2: MK4, MK7, MK8, and MK9. The form of vitamin K that has the most significance for our purposes here is MK7, a newer and longer acting form with more practical applications.

Most vitamin K2 supplements are in the form MK7.

MK7 is extracted from the Japanese fermented soy product called NATTO. You could actually get loads of MK7 from consuming natto as it is relatively inexpensive, and is available in most Asian food markets. Few people, however, tolerate its smell and slimy texture, so most people who find natto unpalatable prefer to take a supplement…..........

*In the comments section:

sayerji-Posted On Mar 25, 2011

Myth: Vitamin K should not be consumed while on anticoagulation drugs such as Warfarin (Coumadin).

Contrary Research
1: Blood. 2007 Mar 15;109(6):2419-23. Epub 2006 Nov 16.

   Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin.
.
Patients receiving warfarin who have unstable control of anticoagulation have a significantly lower intake of dietary vitamin K compared with their stable counterparts. We hypothesized that supplementation with oral vitamin K would improve stability in patients with previously unstable control of anticoagulation. Seventy warfarin-treated patients with unstable anticoagulation control were randomly assigned in a double-blinded fashion to receive a daily amount of 150 mug oral vitamin K or placebo orally for 6 months. Measures of stability of anticoagulation control in the 6-month study period were compared with those in the 6 months immediately prior to it. Vitamin K supplementation resulted in a significantly greater decrease in standard deviation of international normalized ratio (INR) compared with placebo (-0.24 +/- 0.14 vs -0.11 +/- 0.18; P < .001) and a significantly greater increase in percentage time within target INR range (28% +/- 20% vs 15% +/- 20%; P < .01).

Anticoagulation control improved in 33 of 35 patients receiving vitamin K supplementation; of these, 19 fulfilled our criteria for having stable control of anticoagulation. However, only 24 of 33 patients receiving placebo demonstrated some degree of improvement, with only 7 patients fulfilling the criteria for having stable control. Concomitant supplementation of vitamin K, perhaps through reducing the relative day-to-day variability in dietary vitamin K intake, can significantly improve anticoagulation control in patients with unexplained instability of response to warfarin.”


articles.mercola.com/sites/articles/archive/2011/03/26/the-delicate-dance-between-vitamins-d-and-k.aspx

I eat natto regularly.. I even kick it up a notch by adding dried natto powder to it the night before.  This makes every serving of natto about 4 times more concentrated.  Works great in helping keep my blood pressure down.

For heart, blood clots and other chronic concerns, I would suggest EDTA as the way to go.  read more here: (oral chelation) http://gordonresearch.com/
and here:
(intravenous chelation) http://www.drcranton.com/chelation.htm

I’m personally on the oral program and I’m really happy with the results to date.

Antipsychotic drugs lead to blood clots
by Jonathan Benson-NaturalNews.com
April 2 2011

(NaturalNews) New research out of the U.K. adds to the growing body of evidence highlighting the dangers of antipsychotic drugs. Data gathered from tens of thousands of patient records reveals that popular antipsychosis drugs like AstraZeneca’s Seroquel, Eli Lilly’s Zyprexa, Johnson & Johnson’s Risperdal and Bristol-Myers Squibb’s Abilify, can cause severe blood clots in patients.

After accounting for other risk factors, researchers determined that such drugs increase blood clot risk by an average of 32 percent. AstraZeneca’s Seroquel, however, was found to be the worst of all, increasing blood clot risk by a whopping 300 percent. And in general, people taking atypical antipsychotic drugs are roughly 73 percent more likely to develop blood clots than people who do not.

“I would consider this an important, but modest increase in risk,” explained Julia Hippisley-Cox, MD, from the the University of Nottingham, to WebMD. She says the study adds to the “accumulating evidence of adverse health events associated with antipsychotics.”

She also explained that antipsychotic drugs are routinely prescribed for off-label uses such as to treat nausea, vertigo and the “agitation” associated with Alzheimer’s disease. Off-label prescribing is not explicitly illegal, but it is highly unethical and threatens the health of patients.

“These drugs are not approved for this use, but they are frequently used,” she went on to say. “I think it is clear these drugs are prescribed too often for these off-label uses.”

Previous studies have linked antipsychotic drugs to blood clot conditions like deep vein thrombosis and pulmonary embolism, while others have shown that they can cause diabetes and even early death. Earlier this year, AstraZeneca paid out a$198 million to settle legal claims from 17,500 patients who were injured by Seroquel.

Sources for this story include:

http://www.reuters.com/article/idUS...

http://www.naturalnews.com/031932_antipsychotic_drugs_blood_clots.html

Vitamin K…Explained
Dr. Mercola

While other nutrients are important for maintaining and promoting your bone health (like vitamin D3, calcium, and magnesium), evidence continues to grow indicating a vital role vitamin K plays in bone metabolism and healthy bone growth.*

In fact it may be the modern day “missing link” to increasing your bone density.

Vitamin K has been linked to osteoblasts, the cells that generate or ‘lay down’ bone and produce a specific protein known as osteocalcin.*

You can think of osteocalcin like the studs in the wall of your house. Basically, osteocalcin acts as the structural framework holding calcium in place in your bones.*

And vitamin K is critical for producing osteocalcin protein.*

Why is this so important? Because osteocalcin cannot perform its job until vitamin K converts it to an active bone-building form.

The bottom line – vitamin K is the ‘key’ that unlocks the door from your bloodstream to let calcium flow into your bones and bone marrow.*

Without this vitamin K key action, you simply wouldn’t have the strong bones you do.* Plus, there’s another area vitamin K plays an important role, particularly vitamin K2.

I mentioned earlier how osteoblasts are important cells responsible for bone formation.

Well, while these osteoblast cells are busy building bone, other cells called osteoclasts are trying to break down bone and remove bone tissue.

Vitamin K2 is so important because, not only has it been shown to stimulate and enhance osteocalcin production, it has also been shown to inhibit osteoclasts and help maintain your bones.*

Just a question about Nattokinase: My husband has had AFib, blood clots, etc. and has now gone off all meds, and is on Nattokinase, but he is rather apprehensive, not knowing how thin his blood is.  Will having a protime test tell him anything? Thanks.

“April 6th, 2011 at 6:26am by Dianne M
Just a question about Nattokinase: My husband has had AFib, blood clots, etc. and has now gone off all meds, and is on Nattokinase, but he is rather apprehensive, not knowing how thin his blood is.  Will having a protime test tell him anything? Thanks.”


I am in the same boat as your husband. I have also stopped taking all of my medications and am using Nattokinase as well as other supplements to manage my blood clot issues. It has been about 6 months. I take 4 caps a day (Now-Nattokinase 100 mg). I drink a lot more water and eat as many fresh, unprocessed foods as possible. I avoid artificial sweeteners (nutrasweet, sucralose), soy and GMO foods, and take supplements (Vit-D, Vit K2, Vit-C, Magnesium citrate, Life Extension Bone Restore and a multiple.

You asked about having a protime test. I haven’t had one done since I took myself off the Warfarin last year. The protime test tells you how well the blood-thinning medications (anti-coagulants) are working to prevent blood clots. If your husband isn’t taking blood thinners, then I fail to see how this test will tell him anything useful.

It is my opinion that a Fibrinogen Activity test would be more telling. Please read about it here:
http://www.labtestsonline.org/understanding/analytes/fibrinogen/sample.html

I eventually plan to get this test to see how well the Nattokinase is working. If my doctor refuses to let me get this test at his lab, I will use another, independent lab (Directlabs) to have it done anyway (WITHOUT a doctor’s order). Directlabs have nurses that can tell you how to interpret the results.

In addition to making sure your husband is properly hydrated (lots of water to keep the blood thin), you might try looking up foods that help Atrial fibrillation. Here is one link.
atrialfibrillationblog.com/foods-that-may-prevent-atrial-fibrillation/

Best of luck to you and your husband. Please post back to let us know how it works.

I am in the same boat as your husband. I have also stopped taking all of my medications and am using Nattokinase as well as other supplements to manage my blood clot issues. It has been about 6 months. I take 4 caps a day (Now-Nattokinase 100 mg). I drink a lot more water and eat as many fresh, unprocessed foods as possible. I avoid artificial sweeteners (nutrasweet, sucralose), soy and GMO foods, and take supplements (Vit-D, Vit K2, Vit-C, Magnesium citrate, Life Extension Bone Restore and a multiple.

You asked about having a protime test. I haven’t had one done since I took myself off the Warfarin last year. The protime test tells you how well the blood-thinning medications (anti-coagulants) are working to prevent blood clots. If your husband isn’t taking blood thinners, then I fail to see how this test will tell him anything useful.

It is my opinion that a Fibrinogen Activity test would be more telling. Please read about it here:
http://www.labtestsonline.org/understanding/analytes/fibrinogen/sample.html

I eventually plan to get this test to see how well the Nattokinase is working. If my doctor refuses to let me get this test at his lab, I will use another, independent lab (Directlabs) to have it done anyway (WITHOUT a doctor’s order). Directlabs have nurses that can tell you how to interpret the results.

In addition to making sure your husband is properly hydrated (lots of water to keep the blood thin), you might try looking up foods that help Atrial fibrillation. Here is one link.
atrialfibrillationblog.com/foods-that-may-prevent-atrial-fibrillation/

Best of luck to you and your husband. Please post back to let us know how it works.
——————————————-
GOOD advice.  I certainly will read up on all you shared. 
Dianne M

Cathie, I hope you are still reading this. My DVT is similar in size and duration as yours. I would not consume natto or take a supplement while on Coumadin, nor would I discontinue blood thinners while there is still clot. That said, I personally love eating natto, and am trying to figure out if there is any way to do it in my current state. AFAIK, if it helps my clot break down even 10% that’s a good thing, not to mention the bonus health benefits of natto. It is an acquired taste to be sure, but is easier to consume when mixed into rice with low-sodium soy sauce, mustard, or a tbsp of furikake (look it up). Cheers.

Do not, I repeat, DO NOT take nattokinase, orally administered. as a substitute for warfarin therapy, to prevent stroke.

Do not believe ANYONE who tells you that taking natto kinase pils will prevent a stroke.

A couple years ago, my 80+-year-old mother, a health food enthusiast, developed atrial fibrilliation.  The doctor wanted her to start warfarin, to prevent stroke.

She did not want to take ‘rat poison’because of all of wafrarin’s undesirable side effects. 

Six months later she suffered a stroke.
A week of hospitalization followed by two weeks of rehabilitation, she was sent home.  She could walk and talk and move all limbs, but, did lose feeling in her left arm.

My husband and I implored he to please take warfarin.  Which she did for about a 14 months.  In the 14 months she was on warfarin, she did not suffer a stroke.

Then she heard about nattokinase.  She decided to quit taking warfarin, and thin her blood naturally with natto kinase.

I printed everything I could find, online, about how nattikinase, administered orally, is ineffective in preventing stroke, and sent it to her. 

She disregarded all evidence to tho contrary, discontinued taking warfarin and started taking nattokinase, instead.

+-7-months later she had another stroke.

Her doctors, this time, put her on a medication called Pradaxa, which supposedly has fewer side effects than warfarin.  My father says my mother now understands she MUST take her medication.

So, please, tell everyone you know, that based upon experience, nattokinase failed at preventing a stroke in at least one health-food enthusiast.

Please, do not risk the well-being of your loved-one, and permit them chart the dangerous course of attempting to replace warfarin therapy with nattokinase pills.  They are useless in preventing stroke.

Thank you so much for sharing this story with us.  My husband was on Nattokinase a few years ago and not on Coumadin, and did get a DVT in his leg.  He said the pain was so excruciating and then having to get so many of the Lovenox shots in his stomach was horribly painful as well. He was trying the Natto again, but started feeling a pain in his leg and got scared and started taking the Coumadin once again. Unfortunately he will have to be on it forever, as the worry is worse than what it could do to him.  So, as much as I would like him to be on all natural supplements, this is the way he will go.  I take nattokinase along with Dan Shen, a Chinese herb that controls my A-Fib, but to mix the drug and the herb is a no-no.  Best to everyone.

I wouldn’t depend solely on Nattokinase to dissolve blood clots if you have A-Fib. A-Fib can release too many clots into your system.  Di-sodium EDTA intravenous reportedly does wonders in controlling A-Fib, though.

More thoughts about Coumadin/Warfarin and alternatives that might make you switch to something less harmful.


A natural alternative to Coumadin
By Dr. Jonathan Wright on 08/12/2010

Question: My doctor really wants to put me on Coumadin. He says the supplements I take just aren’t strong enough. If I take Coumadin, though, I have to stop taking the supplements for fear of excess bleeding, and then I’ll be missing out on their other health benefits. I need help figuring out what to do.

Dr. Wright: Coumadin is one of the all-time worst “hangovers” from the “heyday” of patent medications: No matter how many alternatives there are for it, it just won’t go away. It certainly thins the blood, but it does so by “poisoning and killing off” the vitamin K in your body. Over enough time, the near-total lack of vitamin K will (not “could”—WILL) cause osteoporosis, arterial calcification, cognitive malfunction, and many, many other problems.

Unfortunately, clinical studies are expensive ventures, and unless there’s a patented substance that has enormous profit potential on the other end of all that pricey research, no one is willing to fork over the money to conduct one. And since vitamins, minerals, and nutrients can’t be patented, there just aren’t any double-blind, placebo-controlled studies to “prove” how well they can work to replace patent medications (like Coumadin)—without all the negative side effects associated with those patented substances.

But even without the clinical studies to “back it up,” there is a very good alternative to Coumadin—one I’ve been using in my practice for over 30 years with great success, and it just so happens to be the same supplement used with such great success for RA: Cod liver oil.

Cod liver and other fish oils work by making platelets (the very small element in your blood essential to the clotting process) so slippery that they can’t stick together easily to form a clot.

There is a test (called the “platelet aggregation test”) that can measure how well your blood is responding to all the natural anti-clotting measures you’re already taking, and help you and your doctor determine exactly how much cod liver (or other fish) oil to take.

But, unfortunately, it’s hard to find and expensive—usually $200-$400 each time. That’s why no one taking aspirin as a blood thinner is ever tested to see if the aspirin is actually doing its job. However, over the years, I’ve run many of these tests and have found that 2 to 3 tablespoonfuls of cod liver oil daily were always enough—and not too much—to do the job.

Remember: Whenever you take supplemental oils or essential fatty acids, always take extra vitamin E, as mixed tocopherols, to prevent the oils from oxidizing too rapidly in your body. Take 800-1,000 IU of vitamin E with 2 to 3 tablespoons of cod liver oil each day. And to minimize any gastrointestinal upset, split the cod liver oil into two or three doses. It’s not very tasty stuff, so if necessary, you can blend it with rice or almond milk.

Of course, for those readers who may already be taking Coumadin, it’s never wise to switch from Coumadin to cod liver oil without the advice of a physician skilled and knowledgeable in nutritional and natural medicine; to find one contact the American College for Advancement in Medicine at (800)532-3688 or visit their website, http://www.acam.org.

http://www.healthiertalk.com/natural-alternative-coumadin-2230


—————————————————————————————————Jonathan V. Wright, M.D. has degrees from both Harvard University (cum laude) and the University of Michigan. More than any other doctor, he practically invented the modern science of applied nutritional biochemistry and he has advanced nutritional medicine for nearly three decades.

More helpful info about Nattokinase that may be useful for those who don’t want to take Coumadin/Warfarin


Will Effects Of Nattokinase Be Evident In A Blood Test?
By Dr. Michael Cutler on 05/23/2011


Dear Dr. Cutler,

I had been taking 5 milligrams of warfarin for some time, but stopped several weeks ago and began taking nattokinase to thin my blood. However, I recently went to the lab for a blood check and my INR was at 1.0. I need it increased to a 2.0.

What can I do to achieve this while continuing with the nattokinase?

—James L.

Dear James,

Although I cannot be your treating physician in this, I can tell you that the International Normalization Ratio (INR) and the protime (PT) will not change with nattokinase or with vitamin E (also a blood thinner) because these products do not affect the intrinsic pathway of blood coagulation.

Therefore, by going off your warfarin—an anticoagulant such as Coumadin® used to prevent heart attacks, strokes and blood clots in veins and arteries—your INR will drop to 1 but your blood will still be thinning from the effects of the nattokinase. The challenge is that with nattokinase, you will not be able to do a blood test to give you the assurance that your blood has thinned appropriately.

I urge you to discuss with your family physician any questions or concerns, but I can tell you I have seen the effects clinically from my patients with nattokinase. Plus I have read the studies on mice and humans and I know what I would choose—along with a nutrient-rich, plant-based diet and stress reduction—for any cardiovascular disease condition. It’s your decision.

Years ago (2002) I was diagnosed with irregular heartbeart and the doctor wanted to put me on coumadin.  I said “NO” and he then said I needed something to prevent a stroke so recommended a full aspirin daily.  I’ve been on the full aspirin for 9 years now.  I read that aspirin interferes with zinc absorption and I had lots of problems with colds, and various other problems that related to the need for zinc.  A couple of years ago I started to take 50 mg of zinc every other day and noticed that I didn’t have a cold for over a year.  I then read that it caused cataracts (which I now have to have surgery for both eyes - eyes need zinc also).  So what I’d like to know is -Can I take nattokinese in lieu of the aspirin and how much?  Fortunately, I haven’t had any bleeding from taking aspirin tor 11 years.

Pregnant women shouldn’t use blood thinners.  Another good reason to use Natto instead.

“Need a C-section? Protection from blood clot urged”

news.yahoo.com/c-section-protection-blood-clot-urged-200857734.html

i a have polycthemia vera and i have a pint or more taken from me to keep my scores within range. had a DVT in 2009 and still have swellling in my ankle. i am on 12mg of warfin and 325mg of aspirin daily. heard about nattokinas and want to take this. any advice?

“October 8th, 2010 at 12:13pm by Jack J. Anderson
Thank you for your informative article. What is a safe daily amount of Nattokinase taken as a dietary supplement? Thanks for your time and attention. JJA”

I take 3 Now Nattokinase-100mg, 120 Vcaps a day.

Are you on any other meds?

Best information on NATTO AND NATTOKINASE I have found during my search for the SAFE use of same.  PUBMED gives you the establishment’s answers—-never stop taking coumadin no matter what.  They say NATTO AND NATTOKINASE may be safe but there hasn’t been sufficient clinical trials to confirm whether it is safe or not.  I have been taking NATTOKINASE for 6 months but it still has not controlled my high pressure.

If you can offer a suggestion to help control the high number—my low number stays in the 70’s.

Thanks for the article, it’s really one of it’s kind. Can u please help me with more about ‘the enzymatic aspect of blood clotting’? I ld be grateful if u do so. Thank. D.M

I finished reading the article. Thank you very much for the information, maybe in the future you can make more articles like this. Regards libro electronico

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My husband is 71 and had a heart attack in june. He has struggled with blood thinning drugs because they caused upper digestive tract bleeding from somd old ulcers and erosion. He had now been tkld thst he needs to be on warfarin because he has a clot in his left ventricle. Would nattokinase be a good alternative to reduce the clot especially if warfarin is not tolorated by him.

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