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Nattokinase: Powerful Enzyme Prevents Heart Attack and Stroke

Nattokinase: Powerful Enzyme Prevents Heart Attack and Stroke

Cardiovascular disease is the leading cause of death for men and women

According to the U.S. Centers for Disease Control, each year about 700,000 people suffer a stroke, the leading cause of serious, long-term disability in the United States. The American Heart Association estimates that nearly every year, about 1 million Americans will suffer a heart attack.

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About 700,000 of these will be first-time heart attack sufferers, while approximately 500,000 will be people who have previously had a heart attack. It all adds up to this: contrary to popular belief, heart attack and stroke account for more deaths than all cancers and injuries combined, and one out of every 2.4 deaths is attributable to cardiovascular disease. How is that possible in the richest, most highly educated country on earth?

Most of us all get too little exercise, accumulate too much stress, and eat a poor diet laden with saturated fat, refined sugar and too little fiber. Add to that list the habit of smoking and the answer is quite clear. (Although there is a considerably higher prevalence of cigarette smoking in Japan than in the U.S., mortality from CVD among men in Japan is still less than half of that in the U.S.3) And to make matters worse, a study published in The Journal of the American Medical Association (3/6/2002) indicates that exposure to air pollution can cause some 10,000 fatal heart attacks a year in the U.S.!

Mainstream health care has banded together with the pharmaceutical industry to offer a temporary quick fix for the number one killer of our time. Statin drugs reduce cholesterol. Aspirin and warfarin thin the blood. Anti-hypertension medications reduce blood pressure. Bypass surgery, and angioplasty clear the arteries. Essentially, they all help prolong the life of a patient with cardiovascular disease (CVD). But none of these drugs or procedures is without risk or side effects. Well, we've got good news for you!

CVD risk can be greatly reduced by modifying lifestyle and adding nutritional supplements proven to support cardiovascular health. Most of us are aware that eating a lighter, more balanced diet, quitting tobacco and exercising regularly are enough to head off most cases of heart disease before they ever happen. Now there's something else you can do.

Nattokinase has been shown to support normal blood pressure, dissolve blood clots and prevent them from forming in the first place!

What Is Nattokinase?

Nattokinase is a potent fibrinolytic (anti-clotting) enzyme complex extracted and highly purified from a traditional Japanese food called Natto. Natto is a fermented cheese-like food that has been used in Japanese culture for more than 1,000 years for its popular taste, and as a folk remedy for heart and vascular diseases. Research has shown that Nattokinase supports the body in breaking up and dissolving the unhealthy coagulation of blood. In fact, it has been shown to have four times greater fibrinolytic activity than plasmin.4

How is it made?

Natto is produced by a fermentation process by adding the bacteria Bacillus subtilis to boiled soybeans. The resulting Nattokinase enzyme is produced when Bacillus subtilis acts on the soybeans. While other soy foods contain enzymes, it is only the natto preparation that contains the specific Nattokinase enzyme. How was Nattokinase discovered? Japanese researcher Dr. Hiroyuki Sumi had spent many years searching for a natural thrombolytic agent that could successfully dissolve blood clots associated with heart attacks and stroke. Finally in 1980, after testing more than 173 natural foods, Sumi found what he was looking for.

Natto, a traditional Japanese soy cheese, was dropped onto an artificial thrombus (fibrin) in a petri dish and allowed to stand at 37ºC (approximately body temperature). Over the next 18 hours, the thrombus around the natto completely dissolved! Sumi named the newly discovered enzyme Nattokinase, which means "enzyme in natto." Dr. Sumi remarked that Nattokinase showed "a potency matched by no other enzyme." 56

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Editor's Note:

The natural health solutions described in these article are available through many on-line retailers including those listed below. By clicking these links you help support the important alternative health research we provide.

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These articles are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.


  1. Soy intake shown to reduce mortality rate from cancer and CVD. Nagata C. Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. Int J Epidemiol. 2000 Oct;29(5):832-6. 

  2. Fujita M, Nomura K, Hong K, Ito Y, Asada A, Nishimuro S. Biochem Biophys Res Commun 1993 Dec 30;197(3):1340-7 Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan. 

  3. Clinical Epidemiology of Coronary Heart Disease in Men Aged 40 and Over. August 2004. National Institutes of Health. Sept. 13, 2004. 

  4. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. 

  5. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002. 

  6. Hager, K. et al. Fibrinogen and Aging. Aging (Milano) 1994, 6:133-38.

  7. Heinrich, J. et al. Fibrinogen and factor VII in the prediction of coronary risk. Arterioscler Thromb 1994, 14:54-59. 

  8. Sumi H. Interview With Doctor of Medicine Hiroyuki Sumi. Japan Bio Science Laboratory Co. Ltd. 

  9. Sumi, H. et al. "Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase." Acta haematol 1990, 84: 139-43.

  10. Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003 Jul 25;73(10):1289-98.

  11.  Maruyama M, Sumi H. Effect of Natto Diet on Blood Pressure.JTTAS, 1995.

  12. Nishimura, K. et al. Natto diet was apparently effective in a case of incipient central retinal vein occlusion. Japan Rev Clin Ophthalmol1994, 88:1381-85.

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Is it safe to take Curamin which contains nattokinase when taking 1 baby aspirin and two omega 3 every day.  I was taken off cumadin and told to take aspirin and omega 3 instead and now am trying curamin for pmr.

My cat scan showed there is vascular caldcification involving the abdominal aorta.  There is intramural thrombus with areas of plaque ulceration.  My doctor cannot give me aspirin or Plavix since I have an ulcer.  I was told about Nattokinase and was told to take 2 capsules daily.  Should I take only 1 and will this interfer with my uler.  Thank You.

Thank you for responding, but you did not mention about the blood clot and if it would dissolve it?  Thank you.

from the angiogram, i have 60 % blockages but do not need bypass or angioplasty as further testd results based on stress tests with thilium x ray, the blood flow is ok . one reason is becos i have lots of collaterals being a keen squash player. now on cardiprin (aspirin) , crestor and approval to control borderline hypertension. )natto helps with blood clots but is this same as plagues in arteries?? i very keen to start natto but please advise as i am on also on cardiprin.  ( if need more specifics, let me know so that i can get from medical records tqvm.

Had a pulmonary embolism-put on coumodin-could natto kinase be used instead???

What a wonderful and complete article.  Thank you,

I am on Pradaxa for arrhythmia and would like to know if I can take natto with it or replace Pradaxa

I had a DVT from my ankle to my hip. The calf has cleared out but the femoral area clot won’t budge. It’s been 6 months and I have been on Coumadin since I was diagnosed. I would love to take Natto, would it work even if the clot is 6 months old? Do I talk to my doc to get off Coumadin first?

I have arthrosclerosis in my legs. I am not taking aspirin or any other medication for it since the specialist tells me there is no cure. My Naturopath Dr. has suggested Nattokinase. I have read all the available info. on it but can find little regarding arthrosclerosis.
Any advice?

Thank you

I eat natto regularly.. I even kick it up a notch by adding dried natto powder to it the night before.  This makes every serving of natto about 4 times more concentrated.  Works great in helping keep my blood pressure down.

For heart, blood clots and other chronic concerns, I would suggest EDTA as the way to go.  read more here: (oral chelation)
and here:
(intravenous chelation)

I’m personally on the oral program and I’m really happy with the results to date.

Just a question about Nattokinase: My husband has had AFib, blood clots, etc. and has now gone off all meds, and is on Nattokinase, but he is rather apprehensive, not knowing how thin his blood is.  Will having a protime test tell him anything? Thanks.

I am in the same boat as your husband. I have also stopped taking all of my medications and am using Nattokinase as well as other supplements to manage my blood clot issues. It has been about 6 months. I take 4 caps a day (Now-Nattokinase 100 mg). I drink a lot more water and eat as many fresh, unprocessed foods as possible. I avoid artificial sweeteners (nutrasweet, sucralose), soy and GMO foods, and take supplements (Vit-D, Vit K2, Vit-C, Magnesium citrate, Life Extension Bone Restore and a multiple.

You asked about having a protime test. I haven’t had one done since I took myself off the Warfarin last year. The protime test tells you how well the blood-thinning medications (anti-coagulants) are working to prevent blood clots. If your husband isn’t taking blood thinners, then I fail to see how this test will tell him anything useful.

It is my opinion that a Fibrinogen Activity test would be more telling. Please read about it here:

I eventually plan to get this test to see how well the Nattokinase is working. If my doctor refuses to let me get this test at his lab, I will use another, independent lab (Directlabs) to have it done anyway (WITHOUT a doctor’s order). Directlabs have nurses that can tell you how to interpret the results.

In addition to making sure your husband is properly hydrated (lots of water to keep the blood thin), you might try looking up foods that help Atrial fibrillation. Here is one link.

Best of luck to you and your husband. Please post back to let us know how it works.
GOOD advice.  I certainly will read up on all you shared. 
Dianne M

Cathie, I hope you are still reading this. My DVT is similar in size and duration as yours. I would not consume natto or take a supplement while on Coumadin, nor would I discontinue blood thinners while there is still clot. That said, I personally love eating natto, and am trying to figure out if there is any way to do it in my current state. AFAIK, if it helps my clot break down even 10% that’s a good thing, not to mention the bonus health benefits of natto. It is an acquired taste to be sure, but is easier to consume when mixed into rice with low-sodium soy sauce, mustard, or a tbsp of furikake (look it up). Cheers.

Do not, I repeat, DO NOT take nattokinase, orally administered. as a substitute for warfarin therapy, to prevent stroke.

Do not believe ANYONE who tells you that taking natto kinase pils will prevent a stroke.

A couple years ago, my 80+-year-old mother, a health food enthusiast, developed atrial fibrilliation.  The doctor wanted her to start warfarin, to prevent stroke.

She did not want to take ‘rat poison’because of all of wafrarin’s undesirable side effects. 

Six months later she suffered a stroke.
A week of hospitalization followed by two weeks of rehabilitation, she was sent home.  She could walk and talk and move all limbs, but, did lose feeling in her left arm.

My husband and I implored he to please take warfarin.  Which she did for about a 14 months.  In the 14 months she was on warfarin, she did not suffer a stroke.

Then she heard about nattokinase.  She decided to quit taking warfarin, and thin her blood naturally with natto kinase.

I printed everything I could find, online, about how nattikinase, administered orally, is ineffective in preventing stroke, and sent it to her. 

She disregarded all evidence to tho contrary, discontinued taking warfarin and started taking nattokinase, instead.

+-7-months later she had another stroke.

Her doctors, this time, put her on a medication called Pradaxa, which supposedly has fewer side effects than warfarin.  My father says my mother now understands she MUST take her medication.

So, please, tell everyone you know, that based upon experience, nattokinase failed at preventing a stroke in at least one health-food enthusiast.

Please, do not risk the well-being of your loved-one, and permit them chart the dangerous course of attempting to replace warfarin therapy with nattokinase pills.  They are useless in preventing stroke.

Thank you so much for sharing this story with us.  My husband was on Nattokinase a few years ago and not on Coumadin, and did get a DVT in his leg.  He said the pain was so excruciating and then having to get so many of the Lovenox shots in his stomach was horribly painful as well. He was trying the Natto again, but started feeling a pain in his leg and got scared and started taking the Coumadin once again. Unfortunately he will have to be on it forever, as the worry is worse than what it could do to him.  So, as much as I would like him to be on all natural supplements, this is the way he will go.  I take nattokinase along with Dan Shen, a Chinese herb that controls my A-Fib, but to mix the drug and the herb is a no-no.  Best to everyone.

I wouldn’t depend solely on Nattokinase to dissolve blood clots if you have A-Fib. A-Fib can release too many clots into your system.  Di-sodium EDTA intravenous reportedly does wonders in controlling A-Fib, though.

Years ago (2002) I was diagnosed with irregular heartbeart and the doctor wanted to put me on coumadin.  I said “NO” and he then said I needed something to prevent a stroke so recommended a full aspirin daily.  I’ve been on the full aspirin for 9 years now.  I read that aspirin interferes with zinc absorption and I had lots of problems with colds, and various other problems that related to the need for zinc.  A couple of years ago I started to take 50 mg of zinc every other day and noticed that I didn’t have a cold for over a year.  I then read that it caused cataracts (which I now have to have surgery for both eyes - eyes need zinc also).  So what I’d like to know is -Can I take nattokinese in lieu of the aspirin and how much?  Fortunately, I haven’t had any bleeding from taking aspirin tor 11 years.

i a have polycthemia vera and i have a pint or more taken from me to keep my scores within range. had a DVT in 2009 and still have swellling in my ankle. i am on 12mg of warfin and 325mg of aspirin daily. heard about nattokinas and want to take this. any advice?

Best information on NATTO AND NATTOKINASE I have found during my search for the SAFE use of same.  PUBMED gives you the establishment’s answers—-never stop taking coumadin no matter what.  They say NATTO AND NATTOKINASE may be safe but there hasn’t been sufficient clinical trials to confirm whether it is safe or not.  I have been taking NATTOKINASE for 6 months but it still has not controlled my high pressure.

If you can offer a suggestion to help control the high number—my low number stays in the 70’s.

Thanks for the article, it’s really one of it’s kind. Can u please help me with more about ‘the enzymatic aspect of blood clotting’? I ld be grateful if u do so. Thank. D.M

I finished reading the article. Thank you very much for the information, maybe in the future you can make more articles like this. Regards libro electronico

I would also like to know your comments to the above questions I want to get off coumadin and have been told about nattakonaise as an alternative.

Can nattokinase be taken for blood thinner in place of aspirine with atrial fib? Also with hawthorne, chayenne, gingko, krill oil turmeric e.t.c?

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For those suffering from high blood pressure I would suggest you try passion fruit or even passion fruit leaves. It has worked for me.

Is it still effective if you cut the pill in half for easier swallowing? 
Thank you

Does this have an effect on triglycerides?

The post on the enzyme Nattokinase was very much useful. I am a biology main student and this article allowed ne to know many things on the chances of getting a heart attack. Thanks for sharing the methods to make the enzyme

Great post with this blog. Being a non traditional student is not as difficult as some might think about write an essay for me. Sure we have a lot going on in our lifestyles outside of school but all the other learners have lifestyles other than student life too.

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I developed peripheral artery disease in my late 40s. I had great difficulty in walking. I took nattokinase and serrapeptase on empty stomach 3 times a day. It cleared up my symptoms within 3-4 weeks. I am 60 and doing fine. You experiment to find best maintenance dose. Best time to take a dose is before bed.

Can nattokinase replace Coumadin and TPA ?

Answer: YES

They will tell you that there are no studies to back this up. I will tell you that there never will be any studies done in the US because it will obsolete those drugs. So don’t hold your breath waiting for the studies. China gas done thousands of studies on fibrinolytic enzymes and they found it prevents heart attacks and strokes.

They give disinformation like telling you that Nattokinase is a “blood thinner”. That is wrong. Like TPA, it is a CLOT BUSTER but dirt cheap. It will clear probably 50% of a blockage within 3 to 4 months.

Do not use it with aspirin since it obsoletes aspirin. Plus aspirin causes medical problems like damaged colons. Using a blood thinner and clot buster ritually together could cause other problems.

Empirical experience from many people says that the combination of serrapeptase and nattokinase work best.

The other thing to use is Vitamin K2 with vitamin D3. This will target calcification and even plaque.

Blood pressure is just a symptom. You don’t target symptoms. You focus on the health of your arteries. Be aware that high blood pressure can also be caused by kidney disease. I would bet that most kidney disease is caused by prescription medications. Something like potassium can lower blood pressure also.

Hope this clarifies things for people

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Don’t let them con you. The same people who own the bulk of the stocks in the medical/pharmaceutical industry own the bulk of the stock in the food industry and they’re the same people who think the world has four to five times more people than the earth should have and they want to get rid of the excess, so the quality of our food has and will continue to deteriorate while the government puts organic farmers, small farmers and providers of natural and healthy food products out of business “for the health and safety of the nation” while they poison people with vaccines.

Yeah, it’s hard to believe, but it’s true anyway.

It’s not lack of exercise. It’s the will to kill combined with the love of money. If you don’t believe, good. You have the Internet. Learn how and do your own research. I would have never believed it if I hadn’t found out for myself.

Need to be more selective in the food, it affects our health. All the same, we are responsible for the actions that have made!
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I realize that this is a Natto and Nattokinase promo, but I would like to add, for those who don’t know, don’t forget the Pauling Therapy. It’s much cheaper than Nattokinase and it has benefits in addition to helping prevent heart attacks.

I encourage you to search it… and bewared the lies of the medical and pharmaceutical industries, whose first and foremost concern is increasing their bottom line, not helping anyone’s health.

I say that for more reasons than the 100,000 wrongful deaths _in the U.S. alone_ they cause *every* year.

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