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Huperzine-A: The Proven Therapeutic Treatment for Memory Loss

Health care professionals are sounding the alarm that Alzheimer's disease will be an epidemic of astronomical proportions for the Baby Boom generation. According to a recent report released by Boston University's School of Medicine, women over 55 face a one in four lifetime risk of developing Alzheimer's disease, and men a one in six chance.2 But here's some good news.

Huperzine-A, an alkaloid extracted from a Chinese moss, Huperzia serrata, is showing great promise as a therapeutic treatment for Alzheimer's disease and other memory loss disorders. It has a long history of use in traditional Chinese medicine.3 It has been approved as a drug in China to treat Alzheimer's disease and other age-associated memory impairments, and is marketed in the U.S. as a dietary supplement.4 It also helps improve memory and learning in adolescent students.

How does it work?

First, it's important to understand how acetylcholine works. This messenger molecule is the most abundant and essential neurotransmitter in the brain that is responsible for numerous functions, including many related to cognition and memory. Acetylcholine is released into the synapse, or space between two nerve cells, where it stimulates the transfer of nerve impulses from one nerve cell to another. After the nerve impulse is transmitted, acetylcholinesterase—an enzyme that is found between nerve endings—breaks down acetylcholine into choline and acetate, and the nerve signal ends.

Loss of acetylcholine function is a primary feature of several types of brain dysfunction, including Alzheimer's disease. In Alzheimer's disease and senile dementia, acetylcholine is destroyed too quickly, and consequently the nerve impulse is either too weak to be received or it is incompletely transmitted between nerve cells. A shortage of acetylcholine is considered the most common cause of memory loss, decreased learning ability and intelligence. Additionally, the greatest amount of damage in the Alzheimer's brain is in the cells using acetylcholine.5 Huperzine-A inhibits the activity of acetylcholinesterase, so the breakdown of acetylcholine is slowed and the strength and duration of the nerve impulse is improved. Fortunately, based on scientific studies in both human and animal models, we now know that Huperzine-A makes more acetylcholine available for better brain functioning, and that it is a promising supplement for reversing and/or slowing down Alzheimer's disease and other brain disorders. Animal studies have also shown that Huperzine can protect against environmental poisoning and that it reduces glutamate-induced cell death.6

Scientific studies

In a 1995 double-blind, placebo controlled study at Zhejiang Medical University, in Hangzhou, China, 50 Alzheimer's patients received 200 mcg of Huperzine-A and 53 received a placebo for 8 weeks. All the patients were evaluated with several memory exams, including the Wechsler memory scale and the mini-mental state examination scale. At the end of the study, about 58% (29/50) of the patients treated with Huperzine-A showed significant improvements in their memory, cognitive, and behavioral functions versus only 36% of those receiving the placebo. There were no adverse side effects reported, and the researchers said, "Huperzine is a promising drug for symptomatic treatment of Alzheimer's disease." 7 

In a more recent study, Huperzine-A was tested on 202 mild to moderate Alzheimer's patients at the Peking Medical College Hospital in Beijing, China. One group was given 400 mcg of Huperzine-A per day for 12 weeks, and the other group was given a placebo. All patients were assessed with tests that evaluated their cognitive function, daily life activity and non-cognitive disorders, such as muscle control. The group treated with Huperzine-A showed remarkable improvement in cognition, behavior and mood, in comparison to the placebo group. There were no side effects except for a few reports of very mild insomnia and water retention in a few patients, and these effects were transient.8

Huperzine-A protects against free radicals

In addition to its acetylcholine enhancing effects, Huperzine-A was found to protect against free radical-induced cell toxicity in lab tests.9 This is significant because many modern diseases are believed to be the result of free radical damage. Huperzine has also been shown to dramatically decrease the abnormally elevated free radical activity in both the brain of old animals10, and the blood of Alzheimer's victims11 . This protective effect has been noted by scientists to be a significant additional benefit of Huperzine-A, beyond its acetylcholine enhancing effect.

Reverses effects of amnesia

Scopolamine is a class of drugs that can induce amnesia, which works by interfering with acetylcholine. A study performed on young and old monkeys given the drug showed that Huperzine-A reversed the deficits in performance and memory that result from scopolamine, suggesting that Huperzine-A may benefit cognitive impairments in patients with Alzheimer's disease and other memory disorders.12

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Editor's Note:

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This article is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.


  1. (no authors cited) Huperzine A. Drugs R D. 2004; 5(1): 44-45.

  2. John Fauber. "Lifetime Risk of Stroke and Alzheimer's," Milwaukee Journal Sentinel. March 13, 2003 

  3. Kozikowski AP, Tückmantel W. Chemistry, Pharmacology, and Clinical Efficacy of the Chinese Nootropic Agent Huperzine A., 26 June 2000 

  4. Jiang H, Luo X, Bai D. Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease. Curr Med Chem. 2003 Nov; 10(21): 2231-52.

  5. Picoulin, Kathryn, Reversing Alzheimer's Naturally. 2002, Auburn Hill Publishing Co., Ca.

  6. Zangara A. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacol Biochem Behav. 2003 Jun; 75(3): 675-86. 

  7. Xu SS, Gao ZX, Weng Z, Du ZM, Xu WA, Yang JS, Zhang ML, Tong ZH, Fang YS, Chai XS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao. 1995 Sep; 16(5): 391-5.

  8. Zhang Z, Wang X, Chen Q, Shu L, Wang J, Shan G. Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial. Zhonghua Yi Xue Za Zhi. 2002 Jul 25; 82(14): 941-4. [Article in Chinese] 

  9. Xiao XQ, Yang JW, Tang XC. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci Lett. 1999 Nov 12; 275(2): 73-6.

  10. Shang YZ, Ye JW, Tang XC. Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats. Zhongguo Yao Li Xue Bao. 1999 Sep;20(9):824-8.

  11. Xu SS, Cai ZY, Qu ZW, Yang RM, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao. 1999 Jun;20(6):486-90. 

  12. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther. 1999 Feb; 288(2): 814-9. 

  13. Sun QQ, Xu SS, Pan JL, Guo HM, Cao WQ. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo Yao Li Xue Bao. Acta Pharmacol Sin 1999 Jul; 20(7): 601-3. 

  14. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998;60:377-86.

  15. Tang XC. Huperzine A (shuangyiping): a promising drug for Alzheimer's disease. Zhongguo Yao Li Xue Bao. 1996 Nov; 17(6): 481-4.

  16. Ma XC, Xin J, Wang HX, Zhang T, Tu ZH. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol Sin. 2003 Mar; 24(3): 247-50. 

  17. Takayama H, Katakawa K, Kitajima M, Yamaguchi K, Aimi N. Ten new lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum THUNB. Chem Pharm Bull (Tokyo). 2003 Oct;51(10):1163-9. 

  18. Tan CH, Wang BD, Jiang SH, Zhu DY. New lycopodium alkaloids from Huperzia serrata. Planta Med. 2002 Feb;68(2):188-90. 

  19. Tan CH, Ma XQ, Jiang SH, Zhu DY. Three new hydroxylated serratidine alkaloids from Huperzia serrata. Nat Prod Lett. 2002 Jun;16(3):149-53. 


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