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Eye Drops Containing N-Acetylcarnosine (NAC) Can Prevent Cataracts!

Eye Drops Containing N-Acetylcarnosine (NAC) Can Prevent Cataracts!

Cataracts are a widespread sight-robbing age-related affliction. In the United States alone, Medicare estimates the annual cost at $3.5 billion for the 1.35 million cataract operations performed annually.

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However, a study published in the American Journal of Therapeutics provides further proof that eye drops containing n-acetylcarnosine, abbreviated as NAC, can slowly reverse existing cataracts and prevent new ones from forming.

This study builds upon NAC’s already impressive clinical track record for the prevention and reversal of cataracts. Since the start of this century, NAC has been used by thousands of individuals to treat age-related eye diseases like cataracts, and macular degeneration.

In this study of more than 50,000 elderly individuals, N-acetylcarnosine topical eyedrops target therapy was demonstrated to have significant efficacy, safety, and good tolerability for the prevention and treatment of visual impairment. In their conclusion, the study’s authors wrote:

“Overall, accumulated study data demonstrate that ... N-acetylcarnosine eyedrops, promote healthy vision and prevent vision disability from senile cataracts, primary open-angle glaucoma, age-related macular degeneration, diabetic retinopathy, and aging. N-acetylcarnosine eyedrop therapy is the crown jewel of the anti-aging medical movement and revolutionizes early detection, treatment, and rejuvenation of aging related eye-disabling disorders.”1

Previous studies

In a previous long-term study, these same researchers observed the changes in lens clarity over a 6 to 24 month period for 49 volunteers. The average age of the participants was 65, and all suffered from senile cataracts ranging from minimal to advanced opacification (clouding of the lens).

The patients received either a 1% solution of NAC eye drops or a placebo, as two drops twice a day in each eye. The patients were then evaluated after two months and again after six months.

The evaluations consisted of ophthalmoscopy (glare test), stereocinematagraphic (slit-image) and retro-illumination (photography). A computerized digital analysis then displayed the light scattering and absorbing effects of the centers of each lens.

Here is the outcome after six months

  • 88.9% of the patients who were treated with NAC had an improvement of glare sensitivity (lowest individual score was a 27% improvement, all the way up to a 100% improvement)
  • 41.5% had a significant improvement of the transmissivity of the lens
  • 90% showed an improvement in visual acuity
  • The patients in the placebo group exhibited little change in eye quality at 6 months and a gradual deterioration at 12 to 24 months

Continued improvement

This study also showed that at 24 months the NAC treated group (who already had significant improvement to the quality of their eyesight), sustained these results with continued use of the NAC eye drops. There were no significant side effects noted in any cases throughout the two-year period.1

Another Russian study evaluated two groups of 49 patients (with the average age being 65), who had advanced symptoms of cataracts. After a 24 month course of treatment, the group that was treated with the eye drops had a cumulative positive change when compared with the group that did not receive the eye drops.2

How does NAC work?

The body is made up largely of proteins. As we age, proteins tend to undergo destructive changes due largely to oxidation and interactions with sugars and aldehydes. These interrelated protein modifications include oxidation, carbonylation, cross-linking, glycation, and advanced glycation end product (AGE) formation. These processes contribute to the aging process.

More specifically, cataracts are formed by the glycation of proteins. Glycation occurs when proteins react with sugars and form advanced glycation end products (AGEs). AGEs physically alter proteins, DNA, and lipids, changing their chemical properties. The result of this reaction leads to the discoloration of the eye lens to yellow and brown, which consequently results in the impairment of vision.

Studies show that carnosine is effective against all these forms of protein modification. When the NAC eye drops are administered, carnosine competes for the glycating agent on the molecule, and protects cellular structures against aldehydes. Therefore, it is believed that carnosine can slow and help to prevent proteins from cross-linking and becoming a cataract, and break existing cross-links, too.

NAC acts as an antioxidant

Once in the aqueous humor, NAC was shown to act as an antioxidant and enter the lens tissue, and to be particularly effective against potent free radicals, especially the superoxide and the hydroxyl. It is therefore presumed that the antioxidant role of L-carnosine (within the aqueous humor) is a major factor in slowing and preventing the appearance of cataracts. It is also believed that NAC may help in the treatment of eye disorders other than cataracts that are the result of oxidative stress including: glaucoma, retinal degeneration, corneal disorders, ocular inflammation, complications of diabetes mellitus, and systemic diseases.3

NAC appears to act as a universal antioxidant, both in the lipid phase of the cellular lens membranes, and in the aqueous environment. It also protects the crystalline lens from oxidative stress-induced, cross-linking damage.

NAC and nighttime glare

Another benefit users of NAC eye drops report is improved night vision. For many people, driving at night is particularly hazardous because of a phenomenon known as nighttime glare. Stoplights, streetlights and other car’s headlights can appear almost blinding to people who suffer from nighttime glare. The reason for this is light scatters when it hits the lens of the aged eye, resulting in bright streaks of light that impair vision and reduce the contrast between light and dark areas. It’s believed the NAC works like a windshield wiper to remove buildup on the lens of the aged eye resulting in a reduction in nighttime glare.

How much should you use?

NAC eye drops appear to be a unique and safe treatment for cataracts, and offer an exciting new solution to the way that cataracts are controlled. The studies used two drops in each eye twice daily continuously for a 24 month period. But since there is no data on a preventative dosage there’s no way of knowing if one drop twice daily works as well as two drops twice daily. What we do know is that the maximal effect of improvement of visual acuity is obtained within the first three to five months of treatment. Then the goal is to maintain that outcome. Therefore ...

  • As a preventative: Use one drop of NAC eye drops once daily.
  • For existing cataracts: Use two drops twice daily.
  • Then, after cataracts have been reduced to an acceptable level, use a maintenance dose of one drop twice daily.

It’s never too late!

If you currently are cataract-free, you would do well to start protecting your eyesight now with a preventative dose of eye drops containing NAC on a daily basis. If you are already experiencing age-related eyesight issues like cataracts or macular degeneration, you should strongly considering embarking on an aggressive dosing schedule of NAC eye drops. And while some may think differently, it’s never too late to take the necessary steps to protect your eyesight.

Editor's Note:

The natural health solutions described in these article are available through many on-line retailers including those listed below. By clicking these links you help support the important alternative health research we provide.

Visit NutriStand – The Nutrition Newsstand from the Supplement Man for Science-Based Nutritional Supplements!

Visit International Antiaging-Systems for hard to find therapies. They specialize in Tomorrow's Treatments Today™.

Visit – a great way to find competitive deals on supplements offered by many different manufacturers.

Visit VitaE8 - The Ultimate Vitamin E – to learn more about the importance of full-spectrum vitamin E supplements.

These articles are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.


  1. Babizhayev, MA, Micans, P, Guiotto, A, Kasus-Jacobi, A, N-Acetylcarnosine Lubricant Eyedrops Possess All-In-One Universal Antioxidant Protective Effects of L-Carnosine in Aqueous and Lipid Membrane Environments, Aldehyde Scavenging, and Transglycation Activities Inherent to Cataracts: A Clinical Study of the New Vision-Saving Drug N-Acetylcarnosine Eyedrop Therapy in a Database Population of Over 50,500 Patients American Journal of Therapeutics: 30 May 2009 [Epub ahead of print.].

  2. Babizhayev MA, Deyev AI, Yermakova VN, Semiletov YA, Davydova NG, Doroshenko VS, Zhukotskii AV, Goldman IM. Efficacy of N-acetylcarnosine in the treatment of cataracts. Drugs R D 2002;3(2):87-103.

  3. Babizhayev MA, Yermakova VN, Semiletov YA, Deyev AI. The natural histidine-containing dipeptide N-alpha-acetylcarnosine as an antioxidant for ophthalmic use. Biochemistry (Mosc) 2000 May;65(5):588-98.

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Very interesting information.
I know many aged person who have had cataract surgery.  I have a mild case of cataracts

My husband, age 60, has wet macular…he already lost central vision in one eye.  He is getting periodic shots in his better eye (Avastin).  Could these shots help him?

i have age related cataracts [81yrs]not yet bad enough for the surgeon to operate.. he says “maybe next year” ...i look forward to getting the drops & hear what the doc says next year…...regards   brian

Who paid for the study?

NAC is the acronym for N-Acetyl-Cysteine
and has been used for years in labeling, publications, etc.
NAC should not be used for N-Acetyl-Carnosine—  This will only lead to confusion, and perhaps wrong application.

This information is great but could you please provide the links to the above mentioned study? It’s not that we don’t trust you but anyone can say they saw a study.

Found the links, sorry, I didn’t see them initially.

Hi John!

At the end of the article, you can click on the word “References” and it reveals the references for the article.  Each reference has a link to the abstract on PubMed.

Hope this helps…

Smart Publications

Just checked the references. They don’t say who paid for the study.If this is an advertisement then that should be clear and honestly so.

I have a severe reflux reaction to oral NAC supplements.  How would that affect me with the eye drops?

Do you think that NAC would also be helpful in clearing eyefloaters?

My Opthomologist said my cataracts were expanding at warp speed and I would most likely need surgery in about a year. I am currently using 1 drop 3x a day. I am 59 years old, which seems far to young to develop cataracts. I will be reporting back in February of 12’ and let you all know if these really work.

Can i get drops from a high street chemist. What do i ask for.i do not like ordering meds on line

Yes, I am hear to tell you that these drops do work. I have been using Longevity Science Visual Ocuity consistently for a good year and a half, but I also am a vegetarian and eat lots of leafy green vegetables and fruit. My eyesight has improved, the cataracts have not disappeared but they are not getting worse. My night driving vision is much better and my astigmatism has been corrected. I use 3 to 4 drops a day. I find them to be very soothing after a long day and especially when my eyes are tired and ache.

Cataract is widely seen in aged people and it can affect the eye sight badly. Laser treatment is available for cataract but it will be very costly. So this Web Based EMR  eye drop will be a great help for the common people.

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