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Carnosine: The Amazing Anti-Aging Nutrient

Carnosine is a small peptide that contains two amino acids, beta- alanine and histidine. It is found in high concentrations in skeletal muscles, cardiac muscle and the brain.12

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Carnosine supplements have been popular among body-builders and athletes mainly for improving muscular fatigue. Now, based on over 800 studies, it's being viewed as one of the most important supplements for longevity based on its amazing properties. It is also a neuroprotectant, a modulator of enzyme activities, and a chelator of toxic metals.34567

Other Benefits

Although carnosine's other benefits have not been extensively researched, based on preliminary studies done in Russia, it has also been shown to be beneficial for its ability to:

  • boost immunity and reduce inflammation
  • exert anticancer effects
  • promote wound healing, protect against radiation damage and reverse post-radiation syndrome. Laboratory animals treated with carnosine were found to have faster and better wound healing rates compared to controls. This has potential applications to treating burns, wounds following surgery, or during nutritional preparation for surgery.8
  • protect against the formation of gastric ulcers, and help heal existing ulcers910
  • help eradicate Helicobacter pylori, an organism that has been linked to peptic ulcer and stomach cancer11
  • reduce or completely prevent cell damage caused by beta amyloid12, the substance found in the brain of Alzheimer's disease patients
  • help protect against cataract formation
  • protect against the effect of glucose damage and protein oxidation
  • inhibit (or reverse) glycosylation and therefore slow the damaging - and pro-aging - effects of carbohydrate consumption
  • increase muscle strength and endurance
  • improve appearance

Are you getting enough carnosine?

Dietary sources of carnosine incude meat, poultry and fish, but with the decrease in meat consumption, many people are getting less and less carnosine in their diet. But even if you do eat meat, as we naturally age, carnosine levels are reduced. This reduction in muscle carnosine concentration may be one of the causes of the decline in muscle mass, strength and function in the elderly.

Carnosine levels decrease with age

There is a high concentration of carnosine found in actively contracting muscles, and a low concentration found in weakened muscles, such as those affected by muscular dystrophy. In fact, people who suffer from a neuromuscular disease exhibit a 63% decline of muscle concentrations of carnosine, from the years 10 to 70.13

Stress and trauma also contribute to a reduction in carnosine levels, which may be a factor in the increased mortality rate in the elderly following stressful events.14 All the more reason to take a carnosine nutritional supplement.

Antioxidant properties

As a potent antioxidant, carnosine stabilizes and protects the cell membrane by quenching the most destructive of free radicals— the hydroxyl radical—as well as the superoxide, singlet oxygen and the peroxyl radical.

Carnosine prevents lipid peroxidation within the cell membrane, and is believed to be the water-soluble counterpart to vitamin E in protecting cell membranes from oxidative damage.15 During the process of lipid peroxidation, lipids (such as the phospholipids in cell membranes and fatty acids in the bloodstream) are subject to attack by free radicals, which damage them by oxidation.

Carnosine has specifically been shown to block a highly reactive end product of lipid peroxidation called malondialdegyde (MDA).1617 If left unchecked, MDA can cause damage to lipids, enzymes and DNA, and contribute to atherosclerosis, joint inflammation, cataract formation, and aging in general.

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This article is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a physician before embarking on a dietary supplement program.

References

  1. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med1992;13:379-444.

  2. Bonfanti L, Peretto P, De Marchis S, Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 1999;59:333-53.

  3. Klebanov GI, Teselkin YO, Babenkova IV. Effect of carnosine and its components on free-radical reactions. Membr Cell Biol1998;12:89-99. 

  4. Hipkiss AR, Preston JE, Himsworth DT. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann NY Acad Sci 1998;854:37-53.

  5. Hipkiss AR. Carnosine, a protective, anti-aging peptide? Int J Biochem Cell Biol 1998;30:863-8. 

  6. Kudriashov IB, Deev LI, Goncharenko EN, et al. [Radioprotective properties of carnosine] Radiats Biol Radioecol 1999;39:268-71 [in Russian].

  7. Lee JW, Miyawaki H, Bobst EV, et al. Improved functional recovery of ischemic rat hearts due to singlet oxygen scavengers histidine and carnosine. J Mol Cell Cardiol 1999;31:113-21.

  8. Ilipkiss A. et al. Protective effects of carnosine against protein modification mediated by nialondialdchyde and hypochlorite. Bioch Biophys Acta 1998, 1380;46-54.

  9. Nishiwaki H, Kato S, Sugamoto S, et al. Ulcerogenic and healing impairing actions of monochloramine in rat stomachs: effects of zinc L-carnosine, polaprezinc. J Physiol Pharmacol 1999;50:183-95.

  10. Arakawa T, Satoh H, Nakamura A, et al. Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2. Dig Dis Sci1990;35:559-66.

  11. Kashimura H, Suzuki K, Hassan M, et al. Polaprezinc, a mucosal protective agent, in combination with lansoprazole, amoxycillin and clarithromycin increases the cure rate of Helicobacter pylori infection.Aliment Pharmacol Ther 1999;13:483-7.

  12. Preston J et al. Toxic effects of B-amyloid on immortalized rat brain endothelial cell: protection by carnosine, homocarnosine and B-alanine. Neuroscience Letters 1998, 242; 105-108. 

  13. Stuerenburg HJ, Kunze K; Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle Biopsies and rat muscles. Archives of Gerontology and Geriatrics, 1999, 29: 107-113.

  14. Ibid. 

  15. Tarnha M, et al. Hydroxyl radical scavenging by carnosine and Cu(ii)-carm)sine complexes. Int J Radial Biol, 1999 75(9):1 177-1188. 

  16. Hipkiss A. et al. Protective effects of carnosine against MDA-induced toxicity towards cultured rat brain endothelial cells. Neuroscience Letters. 1997. 135-138.

  17. Hipkiss A. et al. Protective effects of carnosine against protein modification mediated by nialondialdchyde and hypochlorite. Bioch Biophys Acta 1998, 1380;46-54.

  18. Stadtman ER. Protein oxidation and aging. Science. 1992; 257(5074):1220-4.

  19. Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997; 272(33):20313-6.

  20. Hipkiss AR, Brownson C. A possible new role for the anti-aging peptide carnosine. Cell Mol Life Sci. 2000; 57(5):747-53. 

  21. Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovascular Research. 1998; 37(3):586-600.

  22. Munch G, Schinzel R, Loske C, et al. Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation end products. Journal of Neural Transmission. 1998; 105(4-5):439-61.

  23. Ilipkiss A, Ghana 14. Carnosine protects proteins against rnelhyiglyoxal-mediated modicatiations. Biochem Biophys Rcs Goinm 1998. 248 (1); 28-32.

  24. Boldyrev AA, Gallant SC, Sukhich GT. Carnosine, the protective, anti-aging peptide. Biosci Rep 1999 Dec;19(6):581-7

4 Comments

see
http://www.lifewave.com/reset

then go in: ” Products” and then in “research”

then in “Published Studies”
and in “Nanoscale CARNOSINE Patches Improve Organ Function.”

It’s wonderful!!!

As a follower of the yogis, I never eat anything that had conscious life. I do eat eggs and dairy products. Would you happen to know how many milligrams of Carnosine are present in a large egg? Is it in the yolk, rather than the white? I often separate my eggs, eat the yolk, and give the whites to the cats.
I’ve been searching all over the internet, and haven’t found this information.
Thanks
Kate

I have to ask you some questions, my first question is if I use these anti agi8ng nutrients will there be any side effects. Especially in pregnancy and my married life. Because there are so many cases in which these side effects are reported. B&G sprayer

 それ以外に、グッチが標準的なのを検証して絶えず高まりに従って、シャネル眼鏡新作各国は各種の手段を通じて(通って)絶えず商品輸入を制限して、グッチ標准に適応するため、新技術の開発を加速して、技術の進歩に頼って出口ベルト通販の商品構造を調整して、製品にアップグレードするように促して、製品構造にハイ・テクノロジーの製品と高付加価値ロエベ財布コピーの製品に向ってモデルチェンジするように促して、すでにバッグになって企業のどうしても重視しなければならないジョルジオ アルマーニベルトコピー問題を製造します。ベルト通販第1巻が表面はまるでとても格にバッグの業界と業界を分析したように強いる外のその他の産業の以前が行う時と現在進行形、大多数の友達は見て分からないと表して、奥深くて計り知れません。いいでしょう、続いて私に更にはっきりジョルジオ アルマーニベルトコピー更に分かりやすい更に屌糸の地の言語でみんなと未来を探求させます――それは表面はまるで永遠にただ辞書の中の永遠に同じく到着することはでき(ありえ)ないその時間のプラダ店舗その世界だけが存在します。

  先に他山の石を少し見に来ます。本文は2つ例を挙げて、ひとつのはみごとな経験を言ったので、ひとつのプラダ店舗は失敗の教訓を言ったのです。

  今にこの時代のこのノード、もしも絶対的真理バッグ新作の少数者を掌握するのは地位が低いと発言は重視されなくなって、ただ恐らく同じくとても不当な待遇を受けて、マーケティング人は通じているのを装って、話題はきっとマーケティング界の革新する手本に機転が利きません:グッチ。私は私を承認しないで通じていて、相反する私はずっとグッチコピー尊重して素人で専門バッグ新作の人を指導して、しかし私は今日もまずみんなとアワモデルの私達のバッグの業界がマーケティングを開拓する時のロエベ財布コピーいくつかが参考にして考えるのを話します。

  グッチのみごとな経験は外部のたくさんの人が見たところあまりに多くファンの経済と社会化のマーケティングので依存するグッチコピーのだ、馬雲とことがある雷軍同台時も、はアワ会社がマーケティングがするのグッチ財布レディースが良いだと言ったことがあります。しかし、私はこれがすべて表象だと感じます!
 現実的なのは、本当に健康財布コピーで持続的発展が可能な市場は1の全体の世代が頭が良くて、けちをつけて、理性的に、0詐欺を働きに対して必ず自己シャネルコピーを表現して足の投票する消費者を使いに我慢して、慣れるのが必要でなければならなくて、億万のグッチ財布レディース愚かで熱狂的なファンではなくて、このミュウミュウ財布スーパーコピー群体は情報で大きく爆発する今日もこれまで離れたことがありません。結果は:アワモデルも非難をひどく受けたのを始めました!最も人に我慢シャネルコピーできなくならせるのは彼の飢餓のマーケティングの理論です。私達はここで考えてみて、アワは妥協しますか?

  私個人は今まですべて感じて、本当シャネル眼鏡新作にアワに才能がすべて現れさせたのはマーケティングではなくて、当然なマーケティングも1つの方面で、最も主要なのはやはり(それとも)1つの高い価格性能比財布コピーの製品の自身でから来て、これは出現して環宇ミュウミュウ財布スーパーコピーの製品に響き渡ってその上また(まだ)この何時までやり遂げました:合理的に信用できる価格、ユーザーがインタラクティブで製造する過程、優良品質ルイヴィトン財布コピーのハードウエア+内容のモデルを研究開発するのに参与します。


  グッチは創始者を共同してその専門書の中でグッチの3つの市場の戦略に言及して、少し細分するのはこの形のです:“して品物に破裂する”が製品のルイヴィトン財布コピー戦略だ、“ファンをする”がユーザーの戦略だ、“メディアからする”がまたマーケティングとと関係がある内容の戦略、どこでしたか?どこはまたマーケティングと関係がありませんか?

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