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Recent Articles
Before you read any further, test yourself
How much do you really know about your body's vascular system? (Answers
below questions)
1) Veins convey blood from the different parts of the body back
to the heart. The arteries carry blood away from the heart.
A. True
B. False
A. True. The veins begin at the capillaries. From here, they eventually
return all the venous blood into the heart, after the blood has nourished
the tissues and taken up waste products.
2) The veins are larger and altogether more numerous than the arteries.
A. True
B. False
A. True. The entire capacity of the venous system is much greater
than that of the arterial system.
3) All the veins in your body are the same size.
A. True
B. False
B. False. The veins that originate at the capillaries are very
tiny venules. Small veins join to form larger ones, and finally all
the venous blood in the body pours into two very large veins that
open into the heart: the superior vena cava carries blood from the
head and arms, and the inferior vena cava carries blood from the trunk
and legs.
4) Veins are thicker and stronger than arteries.
A. True
B. False
B. False. Because veins transport blood at a lower pressure, they
are not as strong as arteries. Veins are cylindrical and have three
layers like arteries, but vein walls are thinner, less elastic and
less muscular than those of the arteries.
5) When you look at your wrist, hands or ankles, your veins appear
blue because the blood flowing through them lacks oxygen until it
is exposed to the air.
A. True
B. False
B. False. The waste-rich blood that flows through the veins has
a deep red, maroon color. Because the walls of the veins are thin,
the waste-rich blood visible through your hands, wrists and ankles
appears blue because your skin refracts lightso the deep red color
of the blood actually appears a little blue from outside the skin.
6) The blood leaving your capillaries takes about 30 minutes to
return to your heart.
A. True
B. False
B. False. It only takes 23 seconds for blood to be pumped from
your heart to your body and back again.
7. Valves located inside the veins keeps waste-rich blood moving
in the proper direction, without allowing it to flow backward.
A. True
B. False
A. True. The vein valves are necessary to keep blood flowing toward
the heart, but they are also necessary to allow blood to flow against
the force of gravity. They are like gates, allowing traffic to move
in one direction. For example, blood that is returning to the heart
from the foot has to be able to flow up the leg. Generally, the force
of gravity would discourage that from happening. The vein valves,
however, provide footholds for the blood as it climbs its way up.
8) A varicose vein is a damaged, bulging blue vein that appears only
in the legs of older women.
A. True
B. False
B. False. Although women are three times more likely to get a
varicose vein than men, a varicose vein can show up as a hemorrhoidin
both men and womenand even in the scrotum, where they are known as
varicoceles.2
9) Pregnancy can trigger varicose veins in women who are predisposed
to having them.
A. True
B. False
A. True. This is mainly the consequence of two things:
- Pressure from the weight of the growing fetus in the womb can
impede the flow of blood through the abdomen and force it back into
the veins in the legs.
- The expanding volume of blood in pregnant women stresses the leg
veins.
10) If varicose veins run in your family, there is nothing you
can do to prevent them.
A. True
B. False
B. False. Exercise, proper nutrition and nutritional supplementation
can help strengthen vascular tone, improve circulation, and delay,
minimize or prevent the onset of varicose veins and their complications.
The Importance of Fiber?
Fiber is the parts of fruits, vegetables, grains, nuts and legumes
that can't be digested by humans. It doesn't contain calories or nutrients
to sustain growth or healing, and it isn't found in meats or dairy
products. But it's absolutely necessary for gastrointestinal health
and apparently for vascular health. Here's why:
There are two types of fiber, insoluble and soluble. Insoluble fiber
is a coarse, chewy material that will not dissolve in water. It's
what we think of as roughage. It holds water in the colon or large
intestine, and decreases the time it takes for materials to move through
the colon (transit time). This is extremely important because it helps
sweep out the toxins that have accumulated in your colon from undigested
and unabsorbed foods. And fast elimination of toxins from your system
is a key to overall health.
Soluble fiber dissolves in water. Some soluble fibers also add to
fecal bulk and increase its water content. The more soluble the fiber,
the more easily it is broken downwhich makes its nutrients more readily
available.
People who consume a high-fiber diet usually empty their colons within
35 hours of eating, whereas people who eat a fiber-depleted diet take
about 77 hours. The difference is that a heavy colon filled with hard
fecal matter compresses veins more than an empty colon. The more pressure
put on veins in your lower trunk means the veins in your legs must
work harder to drive blood back to the heart. Thus, when the leg veins
have to work harder, there's a greater risk of developing varicose
veinsnot to mention the hemorrhoids that often accompany constipation,
which are also a result of not getting enough fiber.
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Remarkable Plant Extracts Treat Varicose Veins and Hemorrhoids
( And Conventional Medicine
Has Almost Nothing to Offer )
- Learn why varicose veins are a potentially serious issue that
should not be ignored
- Reduce edema (swelling), especially in the legs
- Stop the pain and itching of hemorrhoids
- Reduce your risk of varicose veins
even if they run
in your family
- Feel relief from the sensations of heaviness and tingling in
your lower legs
The most common form of vascular disease is varicose veins which
usually manifests as incapacitating bulging veins in the legs, and/or
painful and itchy hemorrhoids. But varicose veins are much more than
a nuisance
if you ignore them, they could be fatal.
Varicose veins in the legs are typically treated with compression
stockings, and hemorrhoids with over-the-counter topical ointments.
And, when the going really gets rough, patients can choose from a
variety of surgical procedures. But these treatments are often ineffective,
expensive, unpleasant, risky, and can be accompanied by complications.
So patients tend to put off until tomorrow what they should address
today
and then aggressive intervention may become necessary.
Each year, approximately 2.5 million Americans are severely disabled
by varicose veins. But you don't have to be one of them.1
In this special report, you'll learn about the latest studies on 3
groundbreaking herbs proven to safely and effectively help treat and
prevent varicose veins
so you can finally take charge of your vascular
health.
What are varicose veins?
Varicose veins and hemorrhoids are painful, incapacitating and disfiguring,
and mainstream doctors have few options to offer other than compression
stockings or surgery.
The good news is we have the information you need to support vascular
health
and prevent unsightly and painful veins!
The word varicose comes from the Latin root "varix",
which means "twisted"and it makes sense because varicose veins
look like twisted and bulging dark purple or blue cords that are raised
above the surface of the skin. Any vein can become varicose, but the
veins most commonly affected are those on the backs of the calves or
on the inside of the leg, anywhere from the groin to the anklebecause
walking and standing increases the pressure in the veins in your lower
body.
Spider veins are similar to varicose veins, but they are smaller, and
are usually red or blue in color, and closer to the surface of the skin.
They have short jagged lines that appear as a tree branch or spider
web. Spider veins can be found on both the legs and the face, and can
cover either a very small or large area of skin.3
Varicose veins can have serious complications, including hemorrhaging,
blood clots, phlebitis, swollen ankles, and leg ulcers.
Varicose veins called hemorrhoids are very common in both men and women,
and about 50% of the population in the U.S. have hemorrhoids by age
50. Many health professionals believe they are the direct result of
fiber-depleted diets. It is interesting to note that hemorrhoids are
rare in Third World populations which are typically active and eat a
fiber-rich diet.
Hemorrhoids: answers to the questions you were afraid to ask
Hemorrhoids may result from:
- a fiber-depleted diet
- straining to move stool
- prolonged sitting on a toilet
- pregnancy
- aging (causes weakening of the support structures, which facilitates
prolapse)
- chronic constipation or diarrhea
- anal intercourse
According to a recent scientific review on the subject, "hemorrhoids have plagued humankind since the dawn of history." Unfortunately,
hemorrhoid treatment has not changed much since the days of Hippocrates
thousands of years ago. It has been estimated that 50% of
the population has hemorrhoids by the age of 50.5
Hemorrhoids are very common among pregnant women. The pressure of
the fetus in the abdomen, as well as hormonal changes, cause the hemorrhoidal
vessels to enlarge. These vessels are also placed under severe pressure
during childbirth. For most women, however, hemorrhoids caused by
pregnancy are a temporary problem.
Symptoms
It's possible to have hemorrhoids without any symptoms. The most common
symptom of internal hemorrhoids, however, is bright red blood visible
on the stool, toilet paper, or in the toilet bowl.
Sometimes an internal hemorrhoid protrudes through the anus outside
the body, becoming irritated and painful. This is known as a protruding
hemorrhoid. Symptoms of external hemorrhoids may include painful swelling
or a hard lump around the anus that results when a blood clot forms.
This condition is known as a thrombosed external hemorrhoid. It is
extremely painful and usually requires minor surgery.
Prevention
The best way to prevent hemorrhoids is to keep stools soft so they
pass easilythus decreasing pressure and strainingand to
empty bowels as soon as possible after the urge occurs. Exercising,
drinking 8 to10 glasses of purified water each day, and including
at least 25 grams of fiber in your diet (most Americans get between
8 and 15 grams a day) helps reduce constipation and straining by producing
softer stools that are easier to pass.
Why do varicose veins form
in the first place?
Arteries are lined with muscles that contract and move blood through
the body. Veins don't have their own muscles, so they rely on large
skeletal muscle movement to move blood. One-way valves keep the blood
flowing in the right direction. If the one-way valve becomes weak,
some of the blood can leak back into the vein, collect there, and
then become congested or clogged. This congestion stretches the vein,
injuring the vein lining. The swelling results in a varicose or spider
vein.
The question that many doctors have is: are damaged, stretched veins
the result of malfunctioning valves or do varicose veins begin in
the walls of the vein as they stretch, causing the valves to malfunction?
It's the "what came first, the chicken or the egg?" dilemma.
Scientists have proposed several theories based on these facts:
- Varicose veins are extremely rare in Third World populations who
sit on the floor. When these communities become Westernized and
start sitting on chairs, however, the incidence increases.6
- Varicose veins are almost always found in the legs, indicating
that gravity plays a role in the human upright position.
- The incidence of varicose veins increases with age and seems to
be influenced by diet and lifestyle.
- Women are three times more prone to varicose veins than men, indicating
that female hormones play a major role.
Heredity, a low-fiber diet, weak vein walls, malfunctioning valves
in the veins, unhealthy habits, and A-V shunts (the arterio-venous
connection, in which arterial blood bypasses the capillaries through
an arterio-venous shunt, due to disease, injury or hormones) are all
possible causes of varicose veins.
Varicose veins are rare in Third World nations
As we have already mentioned, people who sit on the floor rather
than on chairs rarely have varicose veins. This theory was presented
in 1913 when a doctor named Miyauchi noticed that varicose veins were
rare among traditional Japanese people who sat on the floor while eating.
He also noticed that when Japanese migrated and adopted a Western lifestyle,
the incidence of varicosities became more common. Similar findings have
been discovered in other cultures where it is traditional to sit on
the floor instead of on chairs.6
Varicose veins are virtually unheard of in Third World populations that
eat a diet high in fiber, and devoid of processed sugars and flours.
According to Howard Baron, M.D. and Barbara Ross, authors of Varicose
Veins: A guide to prevention and treatment, "The low-fiber theory is
supported by studies that have found a significant statistical correlation
between varicose veins and diverticulitis, an illness in which sacs
on the wall of the large bowel become inflamed. Diverticulitis is believed
to be caused by constipation."1
Symptoms associated with fiber deficiency include irregularity, constipation,
high cholesterol, appendicitis, hemorrhoids, irritable bowel syndrome,
colon and colorectol cancer.
Complications with varicose veins
For many people, varicose veins and spider veins are simply a cosmetic
concern. For others, varicose veins can result in severe pain and serious
complications. Varicose veins may also indicate a higher risk of other
vascular disorders.
Varicose veins usually enlarge and worsen over time. They can cause
the legs and feet to swell, and leg muscles may feel fatigued or heavy,
or throb and cramp at night. Also, the skin on the legs and around the
ankles can itch or burn.
In some cases, varicose veins can cause more serious problems and result
in chronic venous insufficiency, a severe clogging of the blood in the
veins that prevents it from returning to the heart.
Venous Insufficiency Syndrome
Veins depend on their own tone and major skeletal muscles to squeeze
blood back to the heart. As blood circulation is slowed, venous blood
escapes from its normal flow path and flows in a reverse direction into
an already congested leg. Venous pooling takes place, and water and
protein leak out. This is chronic venous insufficiency, and its mild
symptoms include leg swelling, pain, soreness, burning, cramping, tiredness,
itching, and "restless legs."
Severe venous disease can result in a myriad of serious problems:
- Phlebitis, an inflamed vein wall, is one of the most common complications
of varicose veins. The onset is sudden, painful and debilitating,
and should be closely monitored because it can develop into thrombophlebitis
(see below).
- Thrombophlebitis starts out like phlebitis, with a slight swelling
of the calf or ankle, a dull ache, and possible weakness, fever,
chills, and loss of appetite. But it is accompanied by a thrombus,
which is more solid and tougher than a blood clot, which forms in
a vein where the blood continues to flow and slows the flow of blood,
causing it to pool. It should not be ignored because it can become
a long-term serious problem.
- Deep vein thrombosis (blood clot) can develop as a result of injury
to the varicose vein. Since deep leg veins are on a straight path
to your heart and lungs, these blood clots can be very dangerous
because of the possibility of it traveling and blocking the heart
and lungs from functioning.
- Post-Thrombotic Syndrome is a result of deep vein thrombosis and
manifests as a variety of problems including: swelling, hardening,
pain and ulcers in the lower leg. This syndrome occurs because deep
vein thrombosis causes permanent damage to the vein valves in the
lower leg. Consequently, the valves allow venous blood to pool,
causing pressure to build in the small veins of the lower leg, ankle
and foot. As pressure builds, fluid seeps from the smaller vessels
and capillaries, drowning layers of tissue under the skin.
- Pulmonary embolism occurs when a clot breaks loose from a vein
wall and travels through the right side of your heart through the
pulmonary artery to your lung. Depending on its size, a pulmonary
embolism can kill you.
According to the American Medical Association, there are 650,000
cases of pulmonary embolism in the U.S. each year, with 30% of those
resulting in death. About 90% of those emboli originate in the lower
extremities, mainly in veins in the calf muscle.
Why are women particularly susceptible to varicose disease?
Scientists believe that progesterone and/or estrogen stretch the veins
by changing the structure of the muscle in the vein walls. This happens
cyclically, and during pregnancy and menopause.
Pregnancy increases the distensibility of vein walls and softens the
valves. At the same time, the veins must accommodate an increased volume
of blood. Additionally, during the last trimester, the enlarged uterus
compresses the inferior vena cava, causing further venous hypertension
and secondary distension of leg veins. Depending on a host of factors,
including genetics, varicose veins that develop during pregnancy may
or may not spontaneously regress after delivery.3
Supporting vascular health before pregnancy with diet, exercise and
nutritional supplements reduces the possibility of varicose veins during
and after pregnancy.
The good news is there is something you can do to support the health
of your veins
and prevent unsightly and painful veins.
Dietary supplementation with three botanical extracts has been shown
to prevent the painful and expensive complications of hemorrhoids and
varicose veins.
3 proven herbal extracts for healthy veins
Horse chestnut, Gotu kola, and Butcher's broom have been shown to:
- improve the appearance of your legs and ankles by reducing swelling
- reduce cramps and tingling in legs
- help circulation on long flights
- alleviate heaviness in the calves
- reduce pain
- improve micro-circulation
- improve capillary flow
- improve vascular tone
- strengthen connective tissue
1) Horse Chestnut
(Aesculus hippocastanum)
The leaves and bark of this tree were traditionally used for venous
congestion symptoms, hemorrhoids, asthma, bronchitis and rheumatism.
Extracts were even marketed by Eli Lilly in the 20th century. Today,
the seed is used medicinally, and has been studied extensively. It is
also the third most frequently prescribed botanical medicine in Germany
especially for hemorrhoids and varicose veins.
Renowned herbalist James Duke, Ph.D. reports in his book The Green
Pharmacy 2 that Varro Tyler, Ph.D., Dean and Professor Emeritus
of Pharmacognosy at Purdue University, singles out Horse chestnut seed
as by far the most effective medicinal plant for treating varicose veins.
Active constituents
Horse chestnut seed contains a complex of triterpene saponins known
collectively as escin, which has been shown to promote vascular circulation.8
It also tones veins, and reduces capillary permeability, inhibiting
the leakage of water and protein into nearby tissues.
Escin also promotes normal tone in the walls of the veins by stimulating
the generation and release of prostaglandins. This, in turn, helps promote
the return of blood to the heart.9
Clinical studies
Escin has been clinically shown to significantly benefit chronic venous
insufficiency, hemorrhoids and post-operative edema.10
Both topical and internal Horse chestnut extracts are popular in Europe
for the treatment of chronic venous insufficiency and varicose veins.
Escin is also an anti-inflammatory and has been shown to reduce edema
(swelling with fluid) following trauma, especially after sports injury,
surgery, and head injury.8,11
More than 100 papers have been written on Horse chestnut. A 1996 study
conducted by 800 German physicians treated more than 5,000 patients
with the symptoms of pain, tiredness, tension and swelling in the leg,
as well as itching and the tendency towards edema. By the end of the
study, all the symptoms had improved markedly or disappeared completely.12
Numerous other studies have examined the safety and effectiveness of
Horse chestnut, and have found that it surpasses placebo and other drugs
for treating pain and swelling, and is compatible with compression stockings
for helping symptoms associated with chronic venous insufficiency.13-16
Those suffering from post-surgery edema have also found relief from
topical application of Horse chestnut extracts, according to preliminary
studies.17
2) Gotu Kola (Centella asiatica)
This herb has been used in India and Indonesia for thousands of years
to heal wounds and relieve leprosy. Gotu kola should not be confused
with kola nut (Cola Nitida), an active ingredient in cola drinks that
contains caffeine. Gotu kola contains no caffeine and is not a stimulant.
Recent studies show that Gotu kola's extract supports vascular problems
in the lower limbs, including venous insufficiency, varicose veins,
and edema in the feet and ankles.
Active constituents
The primary active constituents of Gotu kola are triterpenoids, which
include asiaticoside, madecassic acid and asiatic acid.18
These compounds have been shown to aid in wound healing by increasing
the concentration of antioxidants and restoring inflamed tissues by
increasing blood supply. Because of these properties, Gotu kola has
been traditionally used topically for burns, psoriasis, and the prevention
of scar formation following surgery.
Clinical studies
The herb's ability to improve vein health is well supported by human
studies. A series of studies published in the International Journal
of Angiology in October 2001 tested Gotu kola's ability to improve vascular
health. In one study, researchers gave 40 patients with venous hypertension
(thought to be a precursor to varicose veins) either a placebo or 120
mg of Gotu kola extract daily. After six weeks, the patients who took
the herb experienced a significant reduction in leg swelling and improved
blood flow.19
In another test on human cell cultures, Gotu kola extract was shown
to be especially significant for strengthening the collagen lining of
vein walls, and reducing edema and venous hypertension.20
In a study in which Gotu kola extract was given to subjects who took
a medium-to-long flight, the group that took the extract had less edema
and leg discomfort than the control group, which didn't take anything.21
And in a study of 40 people with venous hypertension, those who took
Gotu kola extract for 6 weeks reported a significant improvement in
microcirculation and edema.22
Additionally, in his book The Healing Power of Herbs, Michael T. Murray,
N.D. reports that in other clinical trials, 80 percent of patients reported
improvement in spider veins, leg ulcers, blood flow, and feelings of
heaviness in the lower legs, numbing and tingling sensations, and night
cramps.23
3. Butcher's Broom (Ruscus aculeatus)
This herb is a member of the lily family, and native to southern and
western Europe and the southern U.S. Although its name comes from its
use as a broom that butchers used to sweep their cutting blocks, the
herb has a long history of treating venous problems like varicose veins
and hemorrhoids.
Active constituents
It contains important flavonoids, and two anti-inflammatory compounds,24-25
ruscogenin and neoruscogenin, that strengthen and tone the veins, and
act as mild diuretics.9 They may also lead to constriction
of the veins which helps blood return from the extremities.
Clinical studies
Both animal and human studies indicate that Butcher's broom extract
is beneficial in the management of venous insufficiency. One meta-analysis
(a statistical analysis that summarizes the results of many studies)
published in the September 2003 issue of International Angiology, included
20 placebo controlled, randomized, double-blind studies and 5 randomized
studies using Cyclo 3 Fort, a combination of Butcher's broom extract,
ascorbic acid and Hesperidin Methyl Chalconea natural flavonoid extract
of citrus fruitvs. placebo.
Cyclo 3 Fort significantly reduced the severity of pain, cramps, heaviness,
edema, and tingling sensations in the lower extremities when compared
to placebo.26
Another study of 166 women with a 14 to 15 year history of venous insufficiency
showed that those who were treated with Butcher's broom extract experienced
a significant improvement in edema, and a decrease in sensations of
heaviness and tingling in the lower legs, when compared to the group
treated with a placebo.27
All three of the mentioned herbal extracts, Horse chestnut, Butcher's
broom, Gotu kola, were also shown to help prevent hemorrhoids.28
Will these botanical extracts make the varicose veins in my legs
disappear?
We can't promise miracles, but if you start using these herbs early,
they can help prevent problems from occurring later. And if your legs
are already disfigured, the extracts will help reduce edemawhich will
improve their appearance.
The most important thing to remember is this: Horse chestnut, Butcher's
broom, and Gotu kola will help stop your varicose veins from getting
worse, and that's priceless
because down the road varicose veins are
a medical conditionnot just a cosmetic nuisancethat can lead to serious
complications.
Caution
Although no adverse effects have been found from Horse chestnut, Gotu
kola or Butcher's broom, they should not be taken by pregnant and lactating
women, or children, without the recommendation of a health practitioner.
Conclusion
The extracts of Horse chestnut, Gotu kola and Butcher's broom offer
safe and effective support and nourishment for healthy veins. When combined
with a healthy diet and lifestyle, these nutrients offer an excellent
addition, and/or alternative to the modalities available for treating
the painful symptoms associated with varicose veins and hemorrhoids.
If you have the tendency toward varicose veins or hemorrhoids, don't
wait until it's too late to reverse a potentially dangerous situation.
Nourish your vascular system now by taking proven nutrients that strengthen
and tone your veins
and minimize the appearance of unsightly varicose
and spider veins.
References:
- Baron, Howard C., M.D., Ross, Barbara A. Varicose
Veins: A Guide to Prevention and Treatment. Facts on File,
Inc. New York, NY. 1995.
- Duke, James A., Ph.D. The Green Pharmacy.
St. Martin's Press, NY, 1997.
- The National Women's Health Information Center,
http://www.4woman.gov/faq/varicose.htm
- National Digestive Diseases Information Clearinghouse,
http://digestive.niddk.nih.gov/ddiseases/pubs/hemorrhoids/
- Orlay G. Haemorrhoidsa review. Aust
Fam Physician. 2003 Jul;32(7):523-6.
Abstract
- Alexander C.J. "Chair-sitting and varicose
veins." Lancet 1972 ; 1 : 822.
Abstract
- Kamen, Betty. New Facts About Fiber.
Nutrition Encounter, Inc., Novato, CA, 1991.
- Guillaume M, Padioleau F. Venotonic effect,
vascular protection, anti-inflammatory and free radical scavenging
properties of horse chestnut extract. Arzneim-Forsch Drug Res
1994;44:25-35.
Abstract
- Presser, Arthur M. Pharmacist's Guide
to Medicinal Herbs. Smart Publications, Petaluma, CA, 2000.
- Sirtori CR. Pharmacol Res. 2001
Sep;44(3):183-93.
- Calabrese C, Preston P. Report of the results
of a double-blind, randomized, single-dose trial of a topical 2%
escin gel versus placebo in the acute treatment of experimentally-induced
hematoma in volunteers. Planta Med 1993;59:394-7.
Abstract
- K, Pohlmann BK. Horse chestnut seed extractan
effective therapy principle in general practice. Drug therapy of
chronic venous insufficiency (article in German) Fortschr Med.
1996 May 30;114(15):196-200.
- Diehm C, Trampisch HJ, Lange S, Schmidt C.
Comparison of leg compression stocking and oral horse chestnut seed
extract therapy in patients with chronic venous insufficiency. Lancet.
1996 Feb 3;347(8997):292-4.
Abstract
- Ottillinger B, Greeske K. Rational therapy
of chronic venous insufficiencychances and limits of the therapeutic
use of horse chestnut seeds extract. BMC Cardiovasc Disord.2001;1(1):5.
Epub 2001 Dec 07.
Abstract
- Siebert U, Brach M, Sroczynski G, Berla K.
Efficacy, routine effectiveness, and safety of horse chestnut seed
extract in the treatment of chronic venous insufficiency. A meta-analysis
of randomized controlled trials and large observational studies.
Int Angiol. 2002 Dec;21(4):305-15.
Abstract
- Pittler MH, Ernst E. Horse Chestnut seed
extract for chronic venous insufficiency: A criteria-based systematic
review. Arch Dermatol 1998;134:1356-60.
Abstract
- Wilhelm K, Felmeier C. Thermometric investigations
about the efficacy of beta-escin to reduce postoperative edema.
Med Klin 1977;72:128-34 [in German].
Abstract
- Kartnig T. Clinical applications of Centella
asiatica (L) Urb. In Herbs, Spices, and Medicinal Plants: Recent
Advances in Botany, Horticulture, and Pharmacology, vol. 3.,
Craker LE, Simon JE (eds). Phoenix, AZ: Oryx Press, 1986, 145-73.
- Incandela L, et al. Total triterpenic fraction
of Centella asiatica in the treatment of venous hypertension: a
clinical, prospective, randomized trial using a combined microcirculatory
model. Angiology. 2001 Oct;52 Suppl 2:S61-7.
Abstract
- Incandela L, Cesarone MR, Cacchio M, De Sanctis
MT, Santavenere C, D'Auro MG, Bucci M, Belcaro G. Total triterpenic
fraction of Centella asiatica in chronic venous insufficiency and
in high-perfusion microangiopathy. Angiology. 2001 Oct;52
Suppl 2:S9-13.
Abstract
- Cesarone MR,, et al. Flight microangiopathy
in medium- to long-distance flights: prevention of edema and microcirculation
alterations with total triterpenic fraction of Centella asiatica.
Angiology. 2001 Oct;52 Suppl 2:S33-7.
Abstract
- Cesarone MR, et al. Microcirculatory effects
of total triterpenic fraction of Centella asiatica in chronic venous
hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry.
Angiology. 2001 Oct;52 Suppl 2:S45-8.
Abstract
- Murray MT. The Healing Power of Herbs.
Rocklin, CA: Prima Publishing, 1995, 180.
- Bouskela E, Cyrino FZ, Marcelon G. Inhibitory
effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone
on increased microvascular permeability induced by various agents
in the hamster cheek pouch. J Cardiovasc Pharmacol 1993;22:225-30.
Abstract
- Bouskela E, Cyrino FZ, Marcelon G. Effects
of Ruscus extract on the internal diameter of arterioles and venules
of the hamster cheek pouch microcirculation. J Cardiovasc Pharmacol
1993;22:221-4.
Abstract
- Boyle P, Diehm C, Robertson C. Meta-analysis
of clinical trials of Cyclo 3 Fort in the treatment of chronic venous
insufficiency. Int Angiol. 2003 Sep;22(3):250-62.
Abstract
- Vanscheidt W, et al. Efficacy and safety
of a Butcher's broom preparation (Ruscus aculeatus L. extract) compared
to placebo in patients suffering from chronic venous insufficiency.
Arzneimittelforschung. 2002;52(4):243-50.
Abstract
- MacKay D. Hemorrhoids and varicose veins:
a review of treatment options. Altern Med Rev. 2001 Apr;6(2):126-40.
Abstract
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